Revisiting the origins of vascular macrophages through the discovery of adventitial macrophage progenitor cells (AMPCs)

Description

Atherosclerosis is one of the leading causes of morbidity and mortality worldwide. Macrophages and other cells of the mononuclear phagocyte system play key roles in its pathogenesis by contributing to atheroma and the formation of proatherogenic vasa vasorum. Traditional paradigms have asserted that macrophages accumulate in atherosclerotic lesions through luminal recruitment and differentiation of blood monocytes. We have identified that murine arteries contain resident progenitor cells within their adventitia that are predisposed to forming macrophages and are increased in atherosclerosis. The discovery, characterisation, origins and relevance of these adventitial macrophage progenitor cells (AMPCs) to vascular health and disease will be discussed in this presentation.

Period	2016
Event title	Freiburg/Adelaide/Nagoya Annual Symposium
Event type	Conference