Only a matter of time (OMIT) Study - A comparison of caloric restriction versus time restriction of food intake

This is a randomised clinical trial to determine whether circadian alignment of food intake maximises the health benefits of caloric restriction in adults aged 35-75 years old. This study compares caloric restriction (CR) diets that restrict the amount of food that is eaten with CR diets that also restrict the time that the food is eaten, to either early or late in the day, on risk factors for type 2 diabetes and cardiovascular diseases over 8 weeks.
The primary outcome is the change in glucose area under curve (AUC) after 3 meals at baseline and at 8 weeks. Secondary end points include insulin area AUC, fasting insulin and glucose, and change in glycated hemoglobin (HbA1c) at baseline and at 8 weeks.