Preclinical Imaging And Research Laboratories

Research output

Research output per year 1985 2014 2015 2016 2017 2018 2019 2020 2021 2024

• 147 Article
• 9 Poster
• 2 Abstract
• 2 Comment/debate
• 2 More
  • 1 Paper
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  Arsenic, cadmium, lead, antimony bioaccessibility and relative bioavailability in legacy gold mining waste

  Kastury, F., Besedin, J., Betts, A. R., Asamoah, R., Herde, C., Netherway, P., Tully, J., Scheckel, K. G. & Juhasz, A. L., 5 May 2024, In: Journal of Hazardous Materials. 469, 133948.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Imaging Glucose Metabolism and Dopaminergic Dysfunction in Sheep (Ovis aries) Brain Using Positron Emission Tomography Imaging Reveals Abnormalities in OVT73 Huntington’s Disease Sheep

  Williams, G. K., Akkermans, J., Lawson, M., Syta, P., Staelens, S., Adhikari, M. H., Morton, A. J., Nitzsche, B., Boltze, J., Christou, C., Bertoglio, D. & Ahamed, M., 6 Nov 2024, In: ACS Chemical Neuroscience. 15, 21, p. 4082-4091 10 p.

  Research output: Contribution to journal › Article › peer-review

• In vivo Assessment of AMP2, a Novel Ceramic-Binding BMP-2, in Ovine Lumbar Interbody Fusion

  Christou, C., Varcoe, T., Williams, G., Heil, T., Leifeld, S., Park, H., Peckham, S., Stewart, D., Greenbaum, J., Wang, T., Pelletier, M., Walsh, W. & Alvarez, L., 2024, (Accepted/In press) In: Spine.

  Research output: Contribution to journal › Article › peer-review

• In Vivo Formation of Adrenal Organoids in a Novel Porcine Model of Adrenocortical Cell Transplantation

  Clarke, B. M., Kireta, S., Johnston, J., Christou, C., Greenwood, J. E., Hurtado, P. R., Manavis, J., Coates, P. T. & Torpy, D. J., 1 Aug 2024, In: Endocrinology. 165, 8, bqae086.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Maternal tadalafil treatment does not increase uterine artery blood flow or oxygen delivery in the pregnant ewe

  Darby, J. R. T., Flouri, D., Cho, S. K. S., Williams, G. K., Holman, S. L., Meakin, A. S., Wiese, M. D., David, A. L., Macgowan, C. K., Seed, M., Melbourne, A. & Morrison, J. L., 2024, (Accepted/In press) In: Experimental Physiology.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Post-Myocardial Infarction Remodeling and Hyperkinetic Remote Myocardium in Sheep Measured by Cardiac MRI Feature Tracking

  Cho, S. K. S., Darby, J. R. T., Williams, G. K., Holman, S. L., Rai, A., Van Amerom, J. F. P., Fan, C. P., Macgowan, C. K., Selvanayagam, J. B., Morrison, J. L. & Seed, M., 2024, (Accepted/In press) In: Journal of Magnetic Resonance Imaging.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Remediation options to reduce bioaccessible and bioavailable lead and arsenic at a smelter impacted site - consideration of treatment efficacy

  Alankarage, D., Betts, A., Scheckel, K. G., Herde, C., Cavallaro, M. & Juhasz, A. L., 15 Jan 2024, In: Environmental Pollution. 341, 122881.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• The influence of polyimide MP-1™ wear particles on a rodent closed fracture healing model

  Oliver, R. A., Wang, T., Christou, C., Buchman, A., Sibony, S. & Walsh, W. R., 1 Jan 2024, In: Journal of Applied Biomaterials and Functional Materials. 22

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  Acute resveratrol exposure does not impact hemodynamics of the fetal sheep

  Darby, J. R. T., Williams, G. K., Cho, S. K. S., Meakin, A. S., Holman, S. L., Quinn, M., Wiese, M. D., Macgowan, C. K., Seed, M. & Morrison, J. L., Jun 2023, In: Physiological Reports. 11, 12, e15749.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)
• 2022

  An alternative to cylinder drums for entering supplies and maintaining germ-free rodent isolators

  Trec, S., De Virgilio, M. & Christou, C., 16 Sept 2022, In: STAR Protocols. 3, 3, 101511.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• A Novel Nanostructured Surface on Titanium Implants Increases Osseointegration in a Sheep Model

  Jones, C. F., Quarrington, R. D., Tsangari, H., Starczak, Y., Mulaibrahimovic, A., Burzava, A. L. S., Christou, C., Barker, A. J., Morel, J., Bright, R., Barker, D., Brown, T., Vasilev, K. & Anderson, P. H., 1 Nov 2022, In: Clinical orthopaedics and related research. 480, 11, p. 2232-2250 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Citations (Scopus)

• Application of soil amendments for reducing PFAS leachability and bioavailability

  Juhasz, A. L., Kastury, F., Herde, C. & Tang, W., 15 Aug 2022, In: Environmental Pollution. 307, 119498.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Brain Alterations in Aged OVT73 Sheep Model of Huntington's Disease: An MRI Based Approach

  Taghian, T., Gallagher, J., Batcho, E., Pullan, C., Kuchel, T., Denney, T., Perumal, R., Moore, S., Muirhead, R., Herde, P., Johns, D., Christou, C., Taylor, A., Passler, T., Pulaparthi, S., Hall, E., Chandra, S., O'Neill, C. A. & Gray-Edwards, H., 2022, In: Journal of Huntington's disease. 11, 4, p. 391-406 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• MRI Characterization of Blood Flow and Oxygen Delivery in the Fetal Sheep whilst Exposed to Sildenafil Citrate

  Morrison, J. L., Williams, G. K., Cho, S. K. S., Saini, B. S., Meakin, A. S., Holman, S. L., Quinn, M., Wiese, M. D., Macgowan, C. K., Seed, M. & Darby, J. R. T., 1 Dec 2022, In: Neonatology. 119, 6, p. 735-744 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Citations (Scopus)
• 2021

  An MRI approach to assess placental function in healthy humans and sheep

  Saini, B. S., Darby, J. R. T., Marini, D., Portnoy, S., Lock, M. C., Yin Soo, J., Holman, S. L., Perumal, S. R., Wald, R. M., Windrim, R., Macgowan, C. K., Kingdom, J. C., Morrison, J. L. & Seed, M., 15 May 2021, In: Journal of Physiology. 599, 10, p. 2573-2602 30 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)

• Comparison of conventional autopsy with post-mortem magnetic resonance, computed tomography in determining the cause of unexplained death

  Femia, G., Langlois, N., Raleigh, J., Gray, B., Othman, F., Perumal, S. R., Semsarian, C. & Puranik, R., Mar 2021, In: Forensic Science, Medicine, and Pathology. 17, 1, p. 10-18 9 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep

  Aujla, T., Darby, J. R. T., Saini, B. S., Lock, M. C., Holman, S. L., Bradshaw, E. L., Perumal, S. R., McInnes, S. J. P., Voelcker, N. H., Wiese, M. D., Macgowan, C. K., Seed, M. & Morrison, J. L., 1 May 2021, In: Experimental Physiology. 106, 5, p. 1166-1180 15 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Longitudinal magnetic resonance spectroscopy and diffusion tensor imaging in sheep (Ovis aries) with quinolinic acid lesions of the striatum: Time-dependent recovery of N-acetylaspartate and fractional anisotropy

  O'Connell, A. B., Kuchel, T. R., Perumal, S. R., Sherwood, V., Neumann, D., Finnie, J. W., Hemsley, K. M. & Jennifer Morton, A., 2021, In: Journal of neuropathology and experimental neurology. 79, 10, p. 1084-1092 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)

• Magnetic resonance imaging of placentome development in the pregnant Ewe

  Flouri, D., Darby, J. R. T., Holman, S. L., Perumal, S. R., David, A. L., Morrison, J. L. & Melbourne, A., Feb 2021, In: Placenta. 105, p. 61-69 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  12 Citations (Scopus)

• Plumbojarosite formation in contaminated soil to mitigate childhood exposure to lead, arsenic and antimony

  Kastury, F., Tang, W., Herde, C., Noerpel, M. R., Scheckel, K. G. & Juhasz, A. L., 15 Sept 2021, In: Journal of Hazardous Materials. 418, 126312.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)

• Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection

  Gao, G. F., Ashtikar, M., Kojima, R., Yoshida, T., Kaihara, M., Tajiri, T., Shanehsazzadeh, S., Modh, H. & Wacker, M. G., 2021, In: Journal of Controlled Release. 329, p. 372-384 13 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

  Lynn, M. A., Eden, G., Ryan, F. J., Bensalem, J., Wang, X., Blake, S. J., Choo, J. M., Chern, Y. T., Sribnaia, A., James, J., Benson, S. C., Sandeman, L., Xie, J., Hassiotis, S., Sun, E. W., Martin, A. M., Keller, M. D., Keating, D. J., Sargeant, T. J. & Proud, C. G. & 3 others, Wesselingh, S. L., Rogers, G. B. & Lynn, D. J., 24 Aug 2021, In: Cell Reports. 36, 8, p. 109564

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• The susceptibility of the aortic root: porcine aortic rupture testing under cardiopulmonary bypass

  Surman, T. L., Abrahams, J. M., Manavis, J., Finnie, J., Christou, C., Williams, G. K., Walls, A., Frantzis, P., Adams, M., Edwards, J., Worthington, M. G. & Beltrame, J., Dec 2021, In: Journal of cardiothoracic surgery. 16, 1, 283.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)
• 2020

  ⁸⁹Zr-pro-MMP-9 F(ab′)₂ detects colitis induced intestinal and kidney fibrosis

  Dmochowska, N., Tieu, W., Keller, M. D., Hollis, C. A., Campaniello, M. A., Mavrangelos, C., Takhar, P. & Hughes, P. A., Dec 2020, In: Scientific reports. 10, 1, 20372.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• COMPARING POST MORTEM MAGNETIC RESONANCE IMAGING AND COMPUTED TOMOGRAPHY TO CONVENTIONAL AUTOPSY IN CASES OF SUDDEN UNEXPECTED DEATH

  Femia, G., Langlois, N., Raleigh, J., Gray, B., Othman, F., Perumal, R., Semsarian, C. & Puranik, R., 28 Mar 2020.

  Research output: Contribution to conference › Poster › peer-review

  Open Access

• Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissues

  Darby, J. R. T., Sorvina, A., Bader, C. A., Lock, M. C., Soo, J. Y., Holman, S. L., Seed, M., Kuchel, T., Brooks, D. A., Plush, S. E. & Morrison, J. L., 1 Mar 2020, In: Journal of Biophotonics. 13, 3, p. e2386 e201960085.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep

  Cho, S. K. S., Darby, J. R. T., Saini, B. S., Lock, M. C., Holman, S. L., Lim, J. M., Perumal, S. R., Macgowan, C. K., Morrison, J. L. & Seed, M., 1 Jul 2020, In: The Journal of Physiology. 598, 13, p. 2557-2573 17 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Fetal cardiovascular response to acute hypoxia during maternal anesthesia

  Varcoe, T. J., Darby, J. R. T., Holman, S. L., Bradshaw, E. L., Kuchel, T., Vaughan, L., Seed, M., Wiese, M. D. & Morrison, J. L., 1 Feb 2020, In: Physiological Reports. 8, 3, e14365.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Increased plasma melatonin in presymptomatic Huntington disease sheep (Ovis aries): Compensatory neuroprotection in a neurodegenerative disease?

  Morton, A. J., Middleton, B., Rudiger, S., Bawden, C. S., Kuchel, T. R. & Skene, D. J., 1 Mar 2020, In: Journal of Pineal Research. 68, 2, e12624.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  22 Citations (Scopus)

• Intra- And Interlaboratory Evaluation of an Assay of Soil Arsenic Relative Bioavailability in Mice

  Bradham, K., Herde, C., Herde, P., Juhasz, A. L., Herbin-Davis, K., Elek, B., Farthing, A., Diamond, G. L. & Thomas, D. J., 4 Mar 2020, In: Journal of Agricultural and Food Chemistry. 68, 9, p. 2615-2622 8 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging

  Saini, B. S., Darby, J. R. T., Portnoy, S., Sun, L., van Amerom, J., Lock, M. C., Soo, J. Y., Holman, S. L., Perumal, S. R., Kingdom, J. C., Sled, J. G., Macgowan, C. K., Morrison, J. L. & Seed, M., 1 Aug 2020, In: Journal of Physiology. 598, 15, p. 3259-3281 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  49 Citations (Scopus)

• Simulated shift work during pregnancy does not impair progeny metabolic outcomes in sheep

  Gatford, K. L., Kennaway, D. J., Liu, H., Schultz, C. G., Wooldridge, A. L., Kuchel, T. R. & Varcoe, T. J., 15 Dec 2020, In: Journal of Physiology. 598, 24, p. 5807-5819 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Technique for comprehensive fetal hepatic blood flow assessment in sheep using 4D flow MRI

  Schrauben, E. M., Darby, J. R. T., Saini, B. S., Holman, S. L., Lock, M. C., Perumal, S. R., Seed, M., Morrison, J. L. & Macgowan, C. K., 1 Sept 2020, In: Journal of Physiology. 598, 17, p. 3555-3567 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Citations (Scopus)

• Umbilical vein infusion of Prostaglandin I2 increases ductus venosus shunting of oxygen rich blood but does not increase cerebral oxygen delivery in the fetal sheep

  Darby, J. R. T., Schrauben, E. M., Saini, B. S., Holman, S. L., Perumal, S. R., Seed, M., Macgowan, C. K. & Morrison, J. L., 1 Nov 2020, In: The Journal of Physiology. 598, 21, p. 4957-4967 11 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)
• 2019

  A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna

  Taghian, T., Marosfoi, M. G., Puri, A. S., Cataltepe, O. I., King, R. M., Diffie, E. B., Maguire, A. S., Martin, D. R., Fernau, D., Batista, A. R., Kuchel, T., Christou, C., Perumal, R., Chandra, S., Gamlin, P. D., Bertrand, S. G., Flotte, T. R., McKenna-Yasek, D., Tai, P. W. L. & Aronin, N. & 3 others, Gounis, M. J., Sena-Esteves, M. & Gray-Edwards, H. L., 16 Nov 2019, (E-pub ahead of print) In: Molecular Therapy.

  Research output: Contribution to journal › Article › peer-review
  74 Citations (Scopus)

• Assessment of a Non-Invasive Brain Oximeter in a Sheep Model of Acute Brain Injury

  Dixon, B., Turner, R. & Christou, C., 2019, In: Medical devices (Auckland, N.Z.). 12, p. 479-487 9 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Differential response to injury in fetal and adolescent sheep hearts in the immediate post in the immediate post-myocardial myocardial myocardial infarction period

  Lock, M. C., Darby, J. R. T., Soo, J. Y., Brooks, D. A., Perumal, R., Selvanayagam, J., Seed, M., MacGowan, C. K., Porrello, E. R., Tellam, R. L. & Morrison, J. L., 5 Mar 2019, In: Frontiers in Physiology. 10, MAR, 208.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus

  Duan, A. Q., Darby, J. R. T., Soo, J. Y., Lock, M. C., Zhu, M. Y., Flynn, L. V., Perumal, R., Macgowan, C. K., Selvanayagam, J., Morrison, J. L. & Seed, M., 3 Dec 2019, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 317, 6, p. R780-R792

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• Fetal Hepatic Flow in Sheep Assessed using 4D flow MRI

  Schrauben, E., Saini, B., Darby, J. R., Holman, S., Yin Soon, J., Lock, M. C., Perumal, S. R., Seed, M. & Morrison, J. L., 15 Feb 2019, (Submitted).

  Research output: Contribution to conference › Abstract › peer-review

• High mobility group box protein 1 neutralization therapy in ovine bacteremia: Lessons learned from an ovine septic shock model incorporating intensive care support

  Stevens, N. E., Nash, C. H., Fraser, C. K., Kuchel, T. R., Maiden, M. J., Chapman, M. J., Diener, K. R. & Hayball, J. D., 30 Aug 2019, In: Experimental and therapeutic medicine. 18, 5, p. 3271-3280 10 p.

  Research output: Contribution to journal › Article › peer-review

• Immuno-PET of innate immune markers CD11b and IL-1b detects inflammation in murine colitis

  Dmochowska, N., Tieu, W., Keller, M. D., Wardill, H. R., Mavrangelos, C., Campaniello, M. A., Takhar, P. & Hughes, P. A., Jun 2019, In: Journal of Nuclear Medicine. 60, 6, p. 858-863 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  28 Citations (Scopus)

• In Vitro, in Vivo, and Spectroscopic Assessment of Lead Exposure Reduction via Ingestion and Inhalation Pathways Using Phosphate and Iron Amendments

  Kastury, F., Smith, E., Doelsch, E., Lombi, E., Donnelley, M., Cmielewski, P. L., Parsons, D. W., Scheckel, K. G., Paterson, D., De Jonge, M. D., Herde, C. & Juhasz, A. L., 2019, In: Environmental Science and Technology.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  36 Citations (Scopus)

• Neurological Examination of Sheep (Ovis aries) with Unilateral and Bilateral Quinolinic Acid Lesions of the Striatum Assessed by Magnetic Resonance Imaging

  O’Connell, A., Sinnott, B., Kuchel, T. R., Perumal, S. R., Fraser, C. K., Hemsley, K. M. & Morton, A. J., 6 Aug 2019, In: Journal of Neurology and Experimental Neuroscience. 05, 02

  Research output: Contribution to journal › Article › peer-review

• Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents

  Sakhtianchi, R., Darvishi, B., Mirzaie, Z., Dorkoosh, F., Shanehsazzadeh, S. & Dinarvand, R., 2019, In: Pharmaceutical development and technology. 24, 9, p. 1063-1075 13 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• PNEUMATOCELES AS A MARKER OF CHEST TRAUMA IN POST-MORTEM CT SCANS

  Langlois, N., Perumal, R. & Sebben, R., 4 Feb 2019, (Submitted).

  Research output: Contribution to conference › Poster › peer-review

• Simulated shift work disrupts maternal circadian rhythms and metabolism, and increases gestation length in sheep

  Gatford, K. L., Kennaway, D. J., Liu, H., Kleemann, D. O., Kuchel, T. R. & Varcoe, T. J., 22 Jan 2019, (E-pub ahead of print) In: Journal of Physiology. 0, 0

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)
• 2018

  18-kDa translocator protein radioligand [¹⁸F]GE-180 as a diagnostic and prognostic biomarker following spinal cord injury

  O'Hare Doig, R., Lewis, M., Keller, M., Clark, J., Jones, C. & Freeman, B. J. C., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

  Wang, D., Zhong, L., Li, M., Li, J., Tran, K., Ren, L., He, R., Xie, J., Moser, R. P., Fraser, C., Kuchel, T., Sena-Esteves, M., Flotte, T. R., Aronin, N. & Gao, G., 14 Dec 2018, In: Molecular Therapy - Methods and Clinical Development. 11, p. 65-72 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  41 Citations (Scopus)

• A novel in vivo large animal model of lumbar spinal joint degeneration

  Wang, T., Pelletier, M. H., Christou, C., Oliver, R., Mobbs, R. J. & Walsh, W. R., 22 May 2018, (E-pub ahead of print) In: Spine Journal.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease

  Pfister, E. L., Dinardo, N., Mondo, E., Borel, F., Conroy, F., Fraser, C., Gernoux, G., Han, X., Hu, D., Johnson, E., Kennington, L., Liu, P., Reid, S. J., Sapp, E., Vodicka, P., Kuchel, T., Morton, A. J., Howland, D., Moser, R. & Sena-Esteves, M. & 4 others, Gao, G., Mueller, C., Difiglia, M. & Aronin, N., Jun 2018, In: Human Gene Therapy. 29, 6, p. 663-673 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  70 Citations (Scopus)