Personal profile
Public Profile
Professor Paul Thomas leads the Genome Editing Laboratory and SA Genome Editing Facility at the University of Adelaide and South Australian Health and Medical Research Institute.
Prof Thomas completed his Ph.D. at the University of Adelaide in 1994. He then moved to the National Institute for Medical Research (London) and completed a 3 year post-doctoral position with the late Dr. Rosa Beddington, who was a world-leader in the field of developmental biology. In 1998, he retuned to Australia with the support of a NHMRC Florey Fellowship and established an independent research group at the Murdoch Institute in Melbourne. In 2006, he moved to the University of Adelaide and in 2008 was awarded a prestigious Pfizer Australia Research Fellowship. In 2014 he was promoted to full Professor and established the SA Genome Editing (SAGE) facility. In 2018, he relocated to the South Australian Health and Medical Research Institute.
Research Interests
Prof Thomas's research focuses on the development of CRISPR/CAS9 genome editing technology for a range of applications including generation and analysis of mouse models for neurodevelopmental disorders and synthetic gene drives for invasive pest suppression. He has published more than 80 scientific articles with >7,000 citations. His research is supported by the USA Defense Advanced Research Projects Agency (DARPA) and the NHMRC.
Collaborations and top research areas from the last five years
-
Multimodal bHLH-PAS DNA binding controls specificity and drives obesity
Bersten, D. C., McDougal, D. P., Sullivan, A. E., Gerassimou, A., Breen, J., Fitzsimmons, R. L., Muscat, G. E. O., Pederson, S., Bruning, J. B., Fan, C. M., Thomas, P. Q., Russell, D. L., Peet, D. J. & Whitelaw, M. L., 13 Jan 2026, In: Nucleic Acids Research. 54, 1, gkaf1352.Research output: Contribution to journal › Article › peer-review
Open Access -
Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development
Congenital Heart Disease Synergy Group, Dec 2026, In: Nature Communications. 17, 1, 1751.Research output: Contribution to journal › Article › peer-review
Open Access -
The LAST mile: evaluating genetic biocontrol as a supplemental tool for eradicating invasive rodents on islands
Birand, A., Hay, B. A., Combs, M., Gierus, L., Horak, K. E., Oh, K. P., Robertson, L. J., Thomas, P. Q., Velasquez-Escobar, A. M., Will, D. J., Maselko, M. & Piaggio, A. J., Apr 2026, In: Evolutionary Applications. 19, 4, e70238.Research output: Contribution to journal › Article › peer-review
Open Access -
Atypical presentations of fetal polycystic kidney disease demonstrates the utility of a genomic autopsy for accurate post-mortem diagnoses
Frank, M. S. B., Bennett, M. K., Ha, T. T., Moore, L., Arts, P., Byrne, A. B., Babic, M., Arriola-Martinez, L., Toubia, J., Brautigan, P. J., Feng, J., Schwarz, Q., Thomas, P. Q., Piltz, S. G., White, M. A., Moghimi, A., Strachan, K., Kwan, E., Springer, A. & Lewit-Mendes, M. & 13 others, , Dec 2025, In: Human Genomics. 19, 1, 132.Research output: Contribution to journal › Article › peer-review
Open Access -
Complementarity and integration of animal and in vitro non-animal pre-clinical model systems– an Australian perspective
Arkell, R. M., Wolvetang, E. J., Gulati, T., Hennessy, J. E., Hill, A. P., Jardé, T., Kueh, A. J., Thomas, P. Q., Winteringham, L. N. & Dobbie, M. S., 6 May 2025, (Accepted/In press) In: Mammalian Genome. 36, 2, p. 482-487 6 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus)