Dr Clayton is a senior consultant nephrologist and epidemiologist at the Royal Adelaide Hospital. He completed his clinical nephrology training in 2010 at Royal Prince Alfred Hospital. He then worked as the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry Epidemiology Fellow, concurrently completing a Masters degree in Clinical Epidemiology followed by a PhD in kidney transplant epidemiology. During this time he also worked as a Senior Lecturer in Evidence Based Medicine at the University of Sydney, establishing a Research Methods course for its medical students. From 2014 he undertook a year of postdoctoral research supported by a Sydney Medical School Medical Foundation Fellowship.

In 2015 he moved to Adelaide to take up his current clinical role and to a leadership position with ANZDATA. As ANZDATA Deputy Executive Officer he edits the Registry's annual report, supervises statisticians and the Epidemiology Fellow, and develops its technical capacity. He oversaw the recent modernisation of the Registry's database that is being used to support the BEST-Fluids and RESOLVE multinational registry randomised trials.