Research output per year
Research output per year
Personal profile
Public Profile
Professor Timothy Hughes is the Precision Medicine Theme Leader at SAHMRI and Consultant Haematologist in the Division of Haematology at SA Pathology. He is also the Cancer Council Chair in Cancer Research, Chair of the International Chronic Myeloid Leukemia Foundation (iCMLf) and Fellow of the Australian Academy of Health and Medical Sciences (AAHMS).
Professor Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays and molecular targets that influence the way CML patients are managed world-wide. He has published over 250 papers that have been cited over 40,000 times.
In October 2017 Professor Hughes was awarded the GSK Award for Research Excellence 2017 for pioneering the use of tyrosine kinase inhibitors (TKIs).
Education/Academic qualification
PhD, Doctor of Medicine , University of New South Wales
… → 1993
Fellowship of the Royal Australasian College of Physicians
… → 1988
Fellowship of the Royal College of Pathologists of Australia
… → 1988
MB BS (Honours), University of New South Wales
… → 1981
External positions
Consultant Haematologist , SA Pathology
Beat Cancer Professor, University of Adelaide
Chair, International CML Foundation
Keywords
- Chronic Myeloid Leukaemia
- Leukaemia
- Cancer
- Haematology
- Treatment Free Remission
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Asciminib monotherapy in patients with CML-CP without BCR::ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results
Mauro, M. J., Hughes, T. P., Kim, D. W., Rea, D., Cortes, J. E., Hochhaus, A., Sasaki, K., Breccia, M., Talpaz, M., Ottmann, O., Minami, H., Goh, Y. T., DeAngelo, D. J., Heinrich, M. C., Gómez-García de Soria, V., le Coutre, P., Mahon, F. X., Janssen, J. J. W. M., Deininger, M., Shanmuganathan, N., & 6 others, 2023, (Accepted/In press) In: Leukemia.Research output: Contribution to journal › Article › peer-review
Open Access -
Asciminib: a new therapeutic option in chronic-phase CML with treatment failure
Yeung, D. T., Shanmuganathan, N. & Hughes, T. P., 16 Jun 2022, In: Blood. 139, 24, p. 3474-3479 6 p.Research output: Contribution to journal › Editorial › peer-review
Open Access8 Citations (Scopus) -
Asciminib for chronic myeloid leukaemia: Next questions
Shanmuganathan, N. & Hughes, T. P., 2022, (Accepted/In press) In: British Journal of Haematology.Research output: Contribution to journal › Review article › peer-review
2 Citations (Scopus) -
Asciminib monotherapy for newly diagnosed chronic myeloid leukemia in chronic phase: the ASC4FIRST phase III trial
Cortes, J. E., Hochhaus, A., Takahashi, N., Larson, R. A., Issa, G. C., Bombaci, F., Ramscar, N., Ifrah, S. & Hughes, T. P., 1 Dec 2022, In: Future Oncology. 18, 38, p. 4161-4170 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (Scopus) -
A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure
Kutyna, M. M., Kok, C. H., Lim, Y., Tran, E. N. H., Campbell, D., Paton, S., Thompson-Peach, C., Lim, K., Cakouros, D., Arthur, A., Hughes, T., Kumar, S., Thomas, D., Gronthos, S. & Hiwase, D. K., 2022, (Accepted/In press) In: Leukemia.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)
Activities
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Hemo 2021 – CML / Asciminib Symposium
Tim Hughes (Invited speaker)
28 Oct 2021Activity: Invited talks and oral presentations › Oral conference presentations and other invited talks
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Blood 2021
Tim Hughes (Invited speaker)
20 Sep 2021Activity: Invited talks and oral presentations › Oral conference presentations and other invited talks
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The 5th Annual Davidoff Hematology International Conference: When Practice Meets Evidence
Tim Hughes (Invited speaker)
2021Activity: Invited talks and oral presentations › Oral conference presentations and other invited talks
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Society of Hematologic Oncology 2021 (SOHO)
Tim Hughes (Invited speaker)
Sep 2021Activity: Invited talks and oral presentations › Oral conference presentations and other invited talks
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CML Medical Expert Talk
Tim Hughes (Invited speaker)
Feb 2021Activity: Invited talks and oral presentations › Oral conference presentations and other invited talks