Personal profile
Public Profile
Professor Timothy Hughes is the Clinical Director in the Precision Cancer Medicine Theme at SAHMRI and Consultant Haematologist at the Royal Adelaide Hospital. He is also Clinical Professor at the University of Adelaide, Inaugural Fellow of the Australian Academy of Health and Medical Sciences (AAHMS) and Fellow of the Australian Academy of Science.
Professor Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays and molecular targets that influence the way CML patients are managed world-wide. He has published over 350 papers that have been cited over 65,000 times.
Professor Hughes has been recognised for his achievements with several national awards including the GSK Award for Research Excellence in 2017 for pioneering the use of tyrosine kinase inhibitors (TKIs) and the Ramaciotti Medal for Excellence in Biomedical Research in 2019. He was also awarded the International CML Foundation Goldman Prize in 2017 for lifetime contributions to improving outcomes for patients with CML.
Education/Academic qualification
PhD, Doctor of Medicine , Doctor of Medicine, the University of New South Wales, University of New South Wales
… → 1993
Fellowship of the Royal Australasian College of Physicians, Fellowship of the Royal Australasian College of Physicians
… → 1988
Fellowship of the Royal College of Pathologists of Australia, Fellowship of the Royal College of Pathologists of Australia
… → 1988
MB BS (Honours), The University of New South Wales MB BS Hons, University of New South Wales
… → 1981
External positions
Consultant Haematologist , SA Pathology
Beat Cancer Professor, University of Adelaide
Chair, International CML Foundation
Keywords
- Chronic Myeloid Leukaemia
- Leukaemia
- Cancer
- Haematology
- Treatment Free Remission
Collaborations and top research areas from the last five years
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Allosteric and ATP-Pocket BCR::ABL1 Inhibition In Vitro, and Characterising Ex Vivo Thrombo-Inflammatory Biomarkers and Thrombin Generation in Asciminib-Treated CML Patients
Omar, M. M. A., Alanazi, M. A., Yeung, D. T., Hughes, T. P. & Jackson, D. E., Apr 2026, In: International Journal of Molecular Sciences. 27, 8, 3623.Research output: Contribution to journal › Article › peer-review
Open Access -
Asciminib demonstrates superior efficacy and safety in newly diagnosed chronic myeloid leukemia in the ASC4FIRST trial
Cortes, J. E., Hughes, T. P., Wang, J., Kim, D. W., Kim, D. D. H., Mayer, J., Goh, Y. T., le Coutre, P., Etienne, G., Kim, I., Andorsky, D. J., Bombaci, F., Issa, G. C., Takahashi, N., Kapoor, S., Jinwal, R., Malek, K., McCulloch, T., Yau, L. & Larson, R. A. & 1 others, , 26 Mar 2026, In: Blood. 147, 13, p. 1433-1446 14 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Enhanced Detection of Splice-Altering Variants in Hematologic Malignancies Using Targeted RNA-Sequencing Data
Maqsood, M., Toubia, J., Wadham, C., Shanmuganathan, N., Shahrin, N. H., Fernandes, A., McConnell, J., Saunders, V., Kaczorowski, D., Kenyon, R. R., Lin, M., Hughes, T. P., Kok, C. H. & Branford, S., Jan 2026, In: Journal of Molecular Diagnostics. 28, 1, p. 39-52 14 p.Research output: Contribution to journal › Article › peer-review
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The PINNACLE study: A multicentre phase II trial of nilotinib in combination with pegylated interferon-α2b in newly diagnosed chronic phase chronic myeloid leukaemia
the Australasian Leukaemia and Lymphoma Group, Feb 2026, In: British Journal of Haematology. 208, 2, p. 599-607 9 p.Research output: Contribution to journal › Article › peer-review
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2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia
Apperley, J. F., Milojkovic, D., Cross, N. C. P., Hjorth-Hansen, H., Hochhaus, A., Kantarjian, H., Lipton, J. H., Malhotra, H., Niederwieser, D., Radich, J., Rousselot, P., Saussele, S., Schiffer, C. A., Silver, R., Soverini, S., Stenke, L., Turkina, A., Casado, L. F., Castagnetti, F. & Cervantes, F. & 18 others, , Aug 2025, In: Leukemia. 39, 8, p. 1797-1813 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access68 Link opens in a new tab Citations (Scopus)
Prizes
Activities
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Leading the CML Revolution
Hughes, T. (Speaker)
Jun 2025Activity: Invited talks and oral presentations › Invited Keynote and Plenary Presentations
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Novartis Launch Meeting: 'Leading the CML Revolution’
Hughes, T. (Invited speaker)
10 Jun 2025Activity: Invited talks and oral presentations › Invited Keynote and Plenary Presentations
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CML Connect Meeting with Chang Gung Memorial Hospital Lankou - Novartis Taiwan
Hughes, T. (Speaker)
24 Apr 2025Activity: Invited talks and oral presentations › Invited Keynote and Plenary Presentations
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New discoveries that will shape future therapies in Chronic Myeloid Leukemia
Hughes, T. (Speaker)
2 Mar 2025 → 29 Mar 2025Activity: Invited talks and oral presentations › Invited Keynote and Plenary Presentations
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'Embarking on a new journey with Scemblix’ Meeting
Hughes, T. (Speaker)
23 Apr 2025Activity: Invited talks and oral presentations › Invited Keynote and Plenary Presentations