Research output per year
Research output per year
Personal profile
Research Interests
Chronic pathological pain arising from our internal (visceral) organs is a colossal global problem, affecting millions of patients with Irritable Bowel Syndrome, Inflammatory Bowel Disease and overactive bladder. Currently working in a group that investigates the underlying causes of chronic visceral pain, and the development of new treatments. The group uses state of the art molecular, anatomical and functional approaches to study mechanisms from the single cell through to in vivo and clinical studies.
Education/Academic qualification
Bachelor's Degree, Biology, Flinders University
1987 → 1989
Award Date: 1 Apr 1990
Keywords
- Gastrointestinal tract
- ibs
- pain
- Endometriosis
- ibd
-
Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity
Castro, J., Harrington, A. M., Lieu, T. M., Garcia-Caraballo, S., Maddern, J., Schober, G., O'Donnell, T., Grundy, L., Lumsden, A. L., Miller, P., Ghetti, A., Steinhoff, M. S., Poole, D. P., Dong, X., Chang, L., Bunnett, N. W. & Brierley, S. M., 17 Oct 2019, In: JCI Insight. 4, 20, e131712.Research output: Contribution to journal › Article › peer-review
Open Access69 Link opens in a new tab Citations (Scopus) -
Serotonin exerts a direct modulatory role on bladder afferent firing in mice
Konthapakdee, N., Grundy, L., O'Donnell, T., Garcia-Caraballo, S., Brierley, S. M., Grundy, D. & Daly, D. M., 1 Nov 2019, In: Journal of Physiology. 597, 21, p. 5247-5264 18 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Link opens in a new tab Citations (Scopus) -
Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain
Castro, J., Grundy, L., Deiteren, A., Harrington, A., O'Donnell, T., Maddern, J., Moore, J., Garcia-Caraballo, S., Rychkov, G., Yu, R., Kaas, Q., Craik, D. J., Adams, D. J. & Brierley, S., Jun 2018, In: British Journal of Pharmacology. 175, 12, p. 2384-2398 15 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Link opens in a new tab Citations (Scopus) -
Structure-Activity Studies Reveal the Molecular Basis for GABA B -Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1
Sadeghi, M., Carstens, B. B., Callaghan, B. P., Daniel, J. T., Tae, H. S., O'Donnell, T., Castro, J., Brierley, S., Adams, D. J., Craik, D. J. & Clark, R. J., 15 Jun 2018, In: ACS Chemical Biology. 13, 6, p. 1577-1587 11 p.Research output: Contribution to journal › Article › peer-review
30 Link opens in a new tab Citations (Scopus) -
Chronic Oral Administration of Linaclotide Inhibits Nociceptive Signalling in Response to Noxious Colorectal Distension in a Model of Chronic Visceral Hypersensitivity
Castro, J., Deiteren, A., Harrington, A., Maddern, J., Moore, J., Garcia-Caraballo, S., O'Donnell, T., Grundy, L. A., Hannig, G., Kurtz, C., Silos-Santiago, A. & Brierley, S., Apr 2017, p. S204.Research output: Contribution to conference › Abstract