[166Dy]Dysporium/[166Ho]Holmium In Vivo generator

Suzanne V. Smith, Nadine Di Bartolo, Saed Mirzadeh, Richard M. Lambrecht, F. F. Knapp, Eric L. Hetherington

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

A novel approach for the delivery of 166 Ho (t 1 2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, 166Dy-an in vivo generator system. A critical question for the in vivo166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [166Dy]Dy/166Ho-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to β- decay of 166Dy. Biodistribution studies of [166Dy]Dy-DTPA showed that the ratio of 166Dy/166Ho in bone remains constant (± 7%) over a 20h period, indicating no Significant in vivo loss of 166Ho from the complex. Increasing the in vivo residence time of [166Dy]Dy-DTPA complex attached to HSA gave similar results.

Original languageEnglish
Pages (from-to)759-764
Number of pages6
JournalApplied Radiation and Isotopes
Volume46
Issue number8
DOIs
Publication statusPublished or Issued - Aug 1995
Externally publishedYes

Keywords

  • Animals
  • Bone Marrow/metabolism
  • Bone and Bones/metabolism
  • Dysprosium/pharmacokinetics
  • Holmium/pharmacokinetics
  • Humans
  • Kinetics
  • Mice
  • Mice, Inbred BALB C
  • Organometallic Compounds/pharmacokinetics
  • Pentetic Acid/analogs & derivatives
  • Radioisotopes/pharmacokinetics
  • Serum Albumin/pharmacokinetics
  • Tissue Distribution

ASJC Scopus subject areas

  • Radiation

Cite this