Abstract
A novel approach for the delivery of 166 Ho (t 1 2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, 166Dy-an in vivo generator system. A critical question for the in vivo166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [166Dy]Dy/166Ho-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to β- decay of 166Dy. Biodistribution studies of [166Dy]Dy-DTPA showed that the ratio of 166Dy/166Ho in bone remains constant (± 7%) over a 20h period, indicating no Significant in vivo loss of 166Ho from the complex. Increasing the in vivo residence time of [166Dy]Dy-DTPA complex attached to HSA gave similar results.
Original language | English |
---|---|
Pages (from-to) | 759-764 |
Number of pages | 6 |
Journal | Applied Radiation and Isotopes |
Volume | 46 |
Issue number | 8 |
DOIs | |
Publication status | Published or Issued - Aug 1995 |
Externally published | Yes |
Keywords
- Animals
- Bone Marrow/metabolism
- Bone and Bones/metabolism
- Dysprosium/pharmacokinetics
- Holmium/pharmacokinetics
- Humans
- Kinetics
- Mice
- Mice, Inbred BALB C
- Organometallic Compounds/pharmacokinetics
- Pentetic Acid/analogs & derivatives
- Radioisotopes/pharmacokinetics
- Serum Albumin/pharmacokinetics
- Tissue Distribution
ASJC Scopus subject areas
- Radiation