A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes

T. Neil Dear; Terence H. Rabbitts

doi:10.1016/0378-1119(94)90576-2

A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes

T. Neil Dear, Terence H. Rabbitts

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The human homeobox gene HOX11 has been identified at the site of a chromosomal translocation in a subset of T-cell acute leukaemias. In the mouse genome, the hox11 family consists of at least three related genes, each of which possesses a highly conserved homeobox. To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family. It maps to a cluster of NK-homeobox genes which function in muscle development. Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related.

Original language	English
Pages (from-to)	225-229
Number of pages	5
Journal	Gene
Volume	141
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(94)90576-2
Publication status	Published or Issued - 20 Apr 1994
Externally published	Yes

Keywords

cDNA
translocation

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(94)90576-2

Cite this

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title = "A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes",

abstract = "The human homeobox gene HOX11 has been identified at the site of a chromosomal translocation in a subset of T-cell acute leukaemias. In the mouse genome, the hox11 family consists of at least three related genes, each of which possesses a highly conserved homeobox. To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family. It maps to a cluster of NK-homeobox genes which function in muscle development. Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related.",

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T1 - A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes

AU - Dear, T. Neil

AU - Rabbitts, Terence H.

PY - 1994/4/20

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N2 - The human homeobox gene HOX11 has been identified at the site of a chromosomal translocation in a subset of T-cell acute leukaemias. In the mouse genome, the hox11 family consists of at least three related genes, each of which possesses a highly conserved homeobox. To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family. It maps to a cluster of NK-homeobox genes which function in muscle development. Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related.

AB - The human homeobox gene HOX11 has been identified at the site of a chromosomal translocation in a subset of T-cell acute leukaemias. In the mouse genome, the hox11 family consists of at least three related genes, each of which possesses a highly conserved homeobox. To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family. It maps to a cluster of NK-homeobox genes which function in muscle development. Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related.

KW - cDNA

KW - translocation

UR - https://www.scopus.com/pages/publications/0028267562

U2 - 10.1016/0378-1119(94)90576-2

DO - 10.1016/0378-1119(94)90576-2

M3 - Article

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AN - SCOPUS:0028267562

SN - 0378-1119

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JO - Gene

JF - Gene

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ER -

A Drosophila melanogaster homologue of the T-cell oncogene HOX11 localises to a cluster of homeobox genes

Abstract

Keywords

ASJC Scopus subject areas

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