A low omega-6 polyunsaturated fatty acid (n-6 PUFA) diet increases omega-3 (n-3) long chain PUFA status in plasma phospholipids in humans

K. E. Wood, A. Lau, E. Mantzioris, R. A. Gibson, C. E. Ramsden, B. S. Muhlhausler

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


This study aimed to determine the effect of reducing the dietary linoleic acid (LA) intake from ~5% to <2.5% energy (%E) on n-3 long chain PUFA (LCPUFA) status in humans. Thirty-six participants followed a <2.5%E LA diet for 4 weeks. Nutrient intakes were estimated from diet diaries and blood samples were collected for assessment of fatty acid composition in plasma and erythrocyte phospholipids. LA intakes were reduced from 4.6%E to 2%E during the low LA intervention (P<0.001) while n-3 LCPUFA intakes were unchanged. LA and total n-6 PUFA content of plasma and erythrocyte phospholipids were significantly reduced after the low LA diet phase (P<0.001). The n-3 LCPUFA content of plasma phospholipids was significantly increased after the low LA diet compared to baseline (6.22% vs. 5.53%, P<0.001). These data demonstrate that reducing LA intake for 4 weeks increases n-3 LCPUFA status in humans in the absence of increased n-3 LCPUFA intake.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Issue number4
Publication statusPublished or Issued - Apr 2014


  • ALA
  • Diet
  • Linoleic acid (LA)
  • Omega-3 PUFA
  • Omega-6 PUFA

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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