A meta-analysis of sperm donation offspring health outcomes

D. H. Adams, R. A. Clark, M. J. Davies, S. De Lacey

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Although the use of donor sperm as a treatment modality for male infertility has become common place, the health outcomes for those conceived has been poorly studied. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the health outcomes of offspring conceived from donor sperm. Eight studies were eligible and included in the review, and of these, three were included in a meta-analysis. Meta-analysis of clinical outcomes showed that donor sperm neonates are not at increased risk of being born of low birth weight (<2500 g), preterm (<37 weeks) or with increased incidences of birth defects, than spontaneously conceived neonates.

Original languageEnglish
Pages (from-to)44-55
Number of pages12
JournalJournal of Developmental Origins of Health and Disease
Issue number1
Publication statusPublished or Issued - 1 Feb 2017
Externally publishedYes


  • Donor conception
  • meta-analysis
  • neonate
  • outcome
  • sperm

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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