A novel serine protease overexpressed in the hair follicles of nude mice

N. Meier; T. N. Dear; T. Boehm

doi:10.1006/bbrc.1999.0600

A novel serine protease overexpressed in the hair follicles of nude mice

N. Meier, T. N. Dear, T. Boehm

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

We have studied changes in gene expression between normal and nude mouse skin. Using the method of representational difference analysis, a cDNA encoding a novel serine protease designated BSSP was cloned. Our results show that in skin this gene is predominantly expressed in the sebaceous gland of the hair follicle and in the distal part of the outer root sheath. Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed.

Original language	English
Pages (from-to)	374-378
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	258
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1999.0600
Publication status	Published or Issued - 10 May 1999
Externally published	Yes

Keywords

Hair follicle
Nude mouse
Overexpression
Sebaceous gland
Serine protease

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1999.0600

Cite this

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abstract = "We have studied changes in gene expression between normal and nude mouse skin. Using the method of representational difference analysis, a cDNA encoding a novel serine protease designated BSSP was cloned. Our results show that in skin this gene is predominantly expressed in the sebaceous gland of the hair follicle and in the distal part of the outer root sheath. Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed.",

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AU - Dear, T. N.

AU - Boehm, T.

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N2 - We have studied changes in gene expression between normal and nude mouse skin. Using the method of representational difference analysis, a cDNA encoding a novel serine protease designated BSSP was cloned. Our results show that in skin this gene is predominantly expressed in the sebaceous gland of the hair follicle and in the distal part of the outer root sheath. Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed.

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KW - Hair follicle

KW - Nude mouse

KW - Overexpression

KW - Sebaceous gland

KW - Serine protease

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JF - Biochemical and Biophysical Research Communications

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A novel serine protease overexpressed in the hair follicles of nude mice

Abstract

Keywords

ASJC Scopus subject areas

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