A systematic review of scope and quality of health economic evaluations conducted in Ethiopia

Daniel Erku, Amanual G. Mersha, Eskinder Eshetu Ali, Gebremedhin B. Gebretekle, Befikadu L. Wubishet, Gizat Molla Kassie, Anwar Mulugeta, Alemayehu B. Mekonnen, Tesfahun C. Eshetie, Paul Scuffham

Research output: Contribution to journalArticlepeer-review


There has been an increased interest in health technology assessment and economic evaluations for health policy in Ethiopia over the last few years. In this systematic review, we examined the scope and quality of healthcare economic evaluation studies in Ethiopia. We searched seven electronic databases (PubMed/MEDLINE, EMBASE, PsycINFO, CINHAL, Econlit, York CRD databases and CEA Tufts) from inception to May 2021 to identify published full health economic evaluations of a health-related intervention or programme in Ethiopia. This was supplemented with forward and backward citation searches of included articles, manual search of key government websites, the Disease Control Priorities-Ethiopia project and WHO-CHOICE programme. The quality of reporting of economic evaluations was assessed using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. The extracted data were grouped into subcategories based on the subject of the economic evaluation, organized into tables and reported narratively. This review identified 34 full economic evaluations conducted between 2009 and 2021. Around 14 (41%) of studies focussed on health service delivery, 8 (24%) on pharmaceuticals, vaccines and devices, and 4 (12%) on public-health programmes. The interventions were mostly preventive in nature and focussed on communicable diseases (n = 19; 56%) and maternal and child health (n = 6; 18%). Cost-effectiveness ratios varied widely from cost-saving to more than US $37 313 per life saved depending on the setting, perspectives, types of interventions and disease conditions. While the overall quality of included studies was judged as moderate (meeting 69% of CHEERS checklist), only four out of 27 cost-effectiveness studies characterized heterogeneity. There is a need for building local technical capacity to enhance the design, conduct and reporting of health economic evaluations in Ethiopia.

Original languageEnglish
Pages (from-to)514-522
Number of pages9
JournalHealth Policy and Planning
Issue number4
Early online date21 Feb 2022
Publication statusPublished or Issued - 12 Apr 2022


  • Ethiopia
  • economic evaluation
  • cost-effectiveness

ASJC Scopus subject areas

  • Health Policy

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