Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis

Samuel Hourigan; Anisyah Ridiandries; Edward Tepper; Jennifer Zhang; Rodney Henriquez; Tania Tsatralis; Zoë E. Clayton; Laura Z. Vanags; Stacy Robertson; S.J. Nicholls; Martin K C Ng; Christina Bursill; Joanne Tan

Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis

Samuel Hourigan, Anisyah Ridiandries, Edward Tepper, Jennifer Zhang, Rodney Henriquez, Tania Tsatralis, Zoë E. Clayton, Laura Z. Vanags, Stacy Robertson, S.J. Nicholls, Martin K C Ng, Christina Bursill, Joanne Tan

Research output: Contribution to journal › Meeting Abstract

Abstract

Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.

Original language	English
Journal	Circulation
Volume	136
Issue number	Suppl 1
Publication status	Published or Issued - 14 Nov 2017

Access to Document

http://circ.ahajournals.org/content/136/Suppl_1/A15013

Cite this

Hourigan, S., Ridiandries, A., Tepper, E., Zhang, J., Henriquez, R., Tsatralis, T., Clayton, Z. E., Vanags, L. Z., Robertson, S., Nicholls, S. J., Ng, M. K. C., Bursill, C., & Tan, J. (2017). Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. Circulation, 136(Suppl 1). http://circ.ahajournals.org/content/136/Suppl_1/A15013

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title = "Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis",

abstract = "Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.",

author = "Samuel Hourigan and Anisyah Ridiandries and Edward Tepper and Jennifer Zhang and Rodney Henriquez and Tania Tsatralis and Clayton, {Zo{\"e} E.} and Vanags, {Laura Z.} and Stacy Robertson and S.J. Nicholls and Ng, {Martin K C} and Christina Bursill and Joanne Tan",

year = "2017",

month = nov,

day = "14",

language = "English",

volume = "136",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis

AU - Hourigan, Samuel

AU - Ridiandries, Anisyah

AU - Tepper, Edward

AU - Zhang, Jennifer

AU - Henriquez, Rodney

AU - Tsatralis, Tania

AU - Clayton, Zoë E.

AU - Vanags, Laura Z.

AU - Robertson, Stacy

AU - Nicholls, S.J.

AU - Ng, Martin K C

AU - Bursill, Christina

AU - Tan, Joanne

PY - 2017/11/14

Y1 - 2017/11/14

N2 - Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.

AB - Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.

M3 - Meeting Abstract

SN - 0009-7322

VL - 136

JO - Circulation

JF - Circulation

IS - Suppl 1

ER -