TY - JOUR
T1 - Acute effects of lixisenatide on energy intake in healthy subjects and patients with type 2 diabetes
T2 - Relationship to gastric emptying and intragastric distribution
AU - Jalleh, Ryan
AU - Pham, Hung
AU - Marathe, Chinmay S.
AU - Wu, Tongzhi
AU - Buttfield, Madeline D.
AU - Hatzinikolas, Seva
AU - Malbert, Charles H.
AU - Rigda, Rachael S.
AU - Lange, Kylie
AU - Trahair, Laurence G.
AU - Feinle-bisset, Christine
AU - Rayner, Christopher K.
AU - Horowitz, Michael
AU - Jones, Karen L.
N1 - Publisher Copyright:
© 2020 by the authors.
PY - 2020/7
Y1 - 2020/7
N2 - Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal (p < 0.001) and distal (p < 0.001) stomach and decreased EI (p < 0.001). EI was not related to the content of the total or proximal stomach but inversely related to the distal stomach at 180 min in health on placebo (r = −0.58, p = 0.03) but not in T2D nor after lixisenatide in either group. In healthy and T2D participants, the reduction in EI by lixisenatide is unrelated to changes in GE/intragastric distribution, consistent with a centrally mediated effect.
AB - Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal (p < 0.001) and distal (p < 0.001) stomach and decreased EI (p < 0.001). EI was not related to the content of the total or proximal stomach but inversely related to the distal stomach at 180 min in health on placebo (r = −0.58, p = 0.03) but not in T2D nor after lixisenatide in either group. In healthy and T2D participants, the reduction in EI by lixisenatide is unrelated to changes in GE/intragastric distribution, consistent with a centrally mediated effect.
KW - Energy intake
KW - Intragastric meal retention
KW - Lixisenatide
KW - Type 2 diabetes
UR - https://www.scopus.com/pages/publications/85087422056
U2 - 10.3390/nu12071962
DO - 10.3390/nu12071962
M3 - Article
C2 - 32630191
AN - SCOPUS:85087422056
SN - 2072-6643
VL - 12
SP - 1
EP - 8
JO - Nutrients
JF - Nutrients
IS - 7
M1 - 1962
ER -