Adult neurogenesis promotes synaptic plasticity in the olfactory bulb

Antoine Nissant; Cedric Bardy; Hiroyuki Katagiri; Kerren Murray; Pierre Marie Lledo

doi:10.1038/nn.2298

Adult neurogenesis promotes synaptic plasticity in the olfactory bulb

Antoine Nissant, Cedric Bardy, Hiroyuki Katagiri, Kerren Murray, Pierre Marie Lledo

Research output: Contribution to journal › Article › peer-review

202 Citations (Scopus)

Abstract

To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis-dependent olfactory learning.

Original language	English
Pages (from-to)	728-730
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	6
DOIs	https://doi.org/10.1038/nn.2298
Publication status	Published or Issued - Jun 2009
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn.2298

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title = "Adult neurogenesis promotes synaptic plasticity in the olfactory bulb",

abstract = "To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis-dependent olfactory learning.",

author = "Antoine Nissant and Cedric Bardy and Hiroyuki Katagiri and Kerren Murray and Lledo, {Pierre Marie}",

note = "Funding Information: We thank M. Alonso for technical help with viral injections and M. Grubb for insightful comments on the manuscript. A.N. was supported by the Pasteur Institute; and P.-M.L., by the Fondation pour la Recherche M{\'e}dicale {\textquoteleft}{\textquoteleft}Equipe FRM,{\textquoteright}{\textquoteright} Agence Nationale de la Recherche (ANR-05-Neur-028-01), Ecole des Neurosciences de Paris and the Groupe Ionis. The Lledo laboratory is a member of the Network of European Neuroscience Institutes (LSHM-CT-2005-019063).",

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doi = "10.1038/nn.2298",

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AU - Nissant, Antoine

AU - Bardy, Cedric

AU - Katagiri, Hiroyuki

AU - Murray, Kerren

AU - Lledo, Pierre Marie

N1 - Funding Information: We thank M. Alonso for technical help with viral injections and M. Grubb for insightful comments on the manuscript. A.N. was supported by the Pasteur Institute; and P.-M.L., by the Fondation pour la Recherche Médicale ‘‘Equipe FRM,’’ Agence Nationale de la Recherche (ANR-05-Neur-028-01), Ecole des Neurosciences de Paris and the Groupe Ionis. The Lledo laboratory is a member of the Network of European Neuroscience Institutes (LSHM-CT-2005-019063).

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N2 - To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis-dependent olfactory learning.

AB - To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis-dependent olfactory learning.

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Adult neurogenesis promotes synaptic plasticity in the olfactory bulb

Abstract

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