Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

Josephine A. Wright; David R. Brown

doi:10.1002/jnr.21461

Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

Josephine A. Wright, David R. Brown

Research output: Contribution to journal › Short survey › peer-review

38 Citations (Scopus)

Abstract

Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals.

Original language	English
Pages (from-to)	496-503
Number of pages	8
Journal	Journal of Neuroscience Research
Volume	86
Issue number	3
DOIs	https://doi.org/10.1002/jnr.21461
Publication status	Published or Issued - 15 Feb 2008
Externally published	Yes

Keywords

Metal
Neurodegeneration
Parkinson's disease
Synuclein

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.1002/jnr.21461

Cite this

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abstract = "Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals.",

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AB - Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals.

KW - Metal

KW - Neurodegeneration

KW - Parkinson's disease

KW - Synuclein

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ER -

Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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