Androgen control of lipid metabolism in prostate cancer: Novel insights and future applications

Lisa M. Butler; Margaret M. Centenera; Johannes V. Swinnen

doi:10.1530/ERC-15-0556

Androgen control of lipid metabolism in prostate cancer: Novel insights and future applications

Lisa M. Butler, Margaret M. Centenera, Johannes V. Swinnen

Blood Cancer Program

Research output: Contribution to journal › Review article › peer-review

78 Citations (Scopus)

Abstract

One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.

Original language	English
Pages (from-to)	R219-R227
Journal	Endocrine-Related Cancer
Volume	23
Issue number	5
DOIs	https://doi.org/10.1530/ERC-15-0556
Publication status	Published or Issued - May 2016

Keywords

Androgens
Lipid metabolism
Lipidomics
Lipogenic enzymes
Phospholipids
Prostate cancer

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Cancer Research

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10.1530/ERC-15-0556

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title = "Androgen control of lipid metabolism in prostate cancer: Novel insights and future applications",

abstract = "One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.",

keywords = "Androgens, Lipid metabolism, Lipidomics, Lipogenic enzymes, Phospholipids, Prostate cancer",

author = "Butler, {Lisa M.} and Centenera, {Margaret M.} and Swinnen, {Johannes V.}",

note = "Funding Information: L M B is supported by a Future Fellowship from the Australian Research Council (FT130101004); M M C is supported by a Young Investigator Award (ID 0412) from the Prostate Cancer Foundation of Australia. L M B, M M C, and J V S acknowledge funding from the Movember Foundation through the Prostate Cancer Foundation of Australia (MRTA3) and the Prostate Cancer Foundation of Australia (ID 2711). J V S acknowledges funding from KU Leuven (GOA/11/009 and C16/15/073) and the Fund for Scientific Research Flanders (FWO) (G.0691.12 and G.0841.15) Publisher Copyright: {\textcopyright} 2016 Society for Endocrinology.",

year = "2016",

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doi = "10.1530/ERC-15-0556",

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N1 - Funding Information: L M B is supported by a Future Fellowship from the Australian Research Council (FT130101004); M M C is supported by a Young Investigator Award (ID 0412) from the Prostate Cancer Foundation of Australia. L M B, M M C, and J V S acknowledge funding from the Movember Foundation through the Prostate Cancer Foundation of Australia (MRTA3) and the Prostate Cancer Foundation of Australia (ID 2711). J V S acknowledges funding from KU Leuven (GOA/11/009 and C16/15/073) and the Fund for Scientific Research Flanders (FWO) (G.0691.12 and G.0841.15) Publisher Copyright: © 2016 Society for Endocrinology.

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AB - One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.

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KW - Lipid metabolism

KW - Lipidomics

KW - Lipogenic enzymes

KW - Phospholipids

KW - Prostate cancer

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Androgen control of lipid metabolism in prostate cancer: Novel insights and future applications

Abstract

Keywords

ASJC Scopus subject areas

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