Antibacterial in vitro activity of fourth generation cephalosporins

Robert Hancock

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Cefpirome, cefepime and cefaclidine are distinguished by having a positively charged quaternary ammonium at carbon 3 of the dihydrothiazone ring. This confers the distinctive advantages of higher permeability across the outer membrane and low affinity for chromosomal cephalosporinases compared to the third generation cephalosporins which lack this quaternary ammonium moiety. These properties result in a marked advantage against resistant mutants of several species containing either derepressed class C chromosomal β-lactamases or variant class A β-lactamases. These unique properties have led to the suggestion that these compounds represent a "fourth generation" of cephalosporins.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalJournal of Chemotherapy
Issue numberSUPPL. 2
Publication statusPublished or Issued - 1 Dec 1996
Externally publishedYes


  • Cefaclidine
  • Cefepime
  • Cefpirome
  • Cephalosporins

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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