Antibiotic resistance in Pseudomonas aeruginosa: Mechanisms and impact on treatment

Robert E.W. Hancock, David P. Speert

Research output: Contribution to journalArticlepeer-review

375 Citations (Scopus)


Pseudomonas aeruginosa continues to be a major cause of infections in Western society, in part because of its high intrinsic resistance to antibiotics. It has been demonstrated that this intrinsic resistance arises from the combination of unusually restricted outer-membrane permeability and secondary resistance mechanisms such as energy-dependent multidrug efflux and chromosomally encoded periplasmic β-lactamase. Given this high level of natural resistance, mutational resistance to most classes of antibiotics can readily arise. In this review we summarize new insights into the mechanisms of resistance, and describe therapeutic approaches that can be used in the face of this continuing resistance threat, as well as new approaches that are being developed to combat resistance. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalDrug Resistance Updates
Issue number4
Publication statusPublished or Issued - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Cancer Research
  • Infectious Diseases
  • Pharmacology (medical)

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