Antimicrobial Activity and Bacterial-Membrane Interaction of Ovine-Derived Cathelicidins

Rachel C. Anderson, Robert E.W. Hancock, Pak Lam Yu

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58 Citations (Scopus)


Three ovine-derived cathelicidins, SMAP29, OaBac5mini, and OaBac7.5mini, were compared with respect to their antibacterial activities and interactions with membranes. SMAP29 was confirmed to be α-helical, broad spectrum, and able to disrupt both the outer and the cytoplasmic membranes at relatively low concentrations. In contrast, the two proline- and arginine-rich OaBac peptides had more-modest antibacterial activities, reduced levels of lipopolysaccharide binding, and a lesser ability to depolarize the cytoplasmic membrane, consistent with a cytoplasmic target.

Original languageEnglish
Pages (from-to)673-676
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number2
Publication statusPublished or Issued - Feb 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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