Antimycobacterial polyynes of Devil's club (Oplopanax horridus), a north american native medicinal plant

M. Kobaisy, Z. Abramowski, L. Lermer, G. Saxena, R. E.W. Hancock, G. H.N. Towers, D. Doxsee, R. W. Stokes

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Abstract

Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae), a medicinal plant of North America. The structures were established by 1H and 13C NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 μg/disk in a disk diffusion assay.

Original languageEnglish
Pages (from-to)1210-1213
Number of pages4
JournalJournal of Natural Products
Volume60
Issue number11
DOIs
Publication statusPublished or Issued - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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