Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

Suthagar Pillai Piaru; Roziahanim Mahmud; Amin Malik Shah Abdul Majid; Zeyad Daoud Mahmoud Nassar

doi:10.1016/S1995-7645(12)60042-X

Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

Suthagar Pillai Piaru
, Roziahanim Mahmud
, Amin Malik Shah Abdul Majid
, Zeyad Daoud Mahmoud Nassar

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC ₅₀ value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC ₅₀ of 77.64 μg/mL comparing to mengkudu oil which exhibits IC ₅₀ of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

Original language	English
Pages (from-to)	294-298
Number of pages	5
Journal	Asian Pacific Journal of Tropical Medicine
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/S1995-7645(12)60042-X
Publication status	Published or Issued - Apr 2012
Externally published	Yes

Keywords

Antiangiogenic
Antioxidant
Essential oil
Morinda citrifolia
Myristica fragrans

ASJC Scopus subject areas

General Medicine

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10.1016/S1995-7645(12)60042-X

Cite this

@article{08435f88cecb42fd819ea91602ada310,

title = "Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia",

abstract = "Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)\% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)\%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.",

keywords = "Antiangiogenic, Antioxidant, Essential oil, Morinda citrifolia, Myristica fragrans",

author = "Piaru, \{Suthagar Pillai\} and Roziahanim Mahmud and \{Abdul Majid\}, \{Amin Malik Shah\} and \{Mahmoud Nassar\}, \{Zeyad Daoud\}",

note = "Funding Information: *Corresponding author: Dr. Roziahanim Mahmud, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. E-mail: suthagar\[email protected] Foundation project: This project was funded by Universiti Sains Malaysia Research University (RU) Grant (1001/PFARMASI/813021).",

year = "2012",

month = apr,

doi = "10.1016/S1995-7645(12)60042-X",

language = "English",

volume = "5",

pages = "294--298",

journal = "Asian Pacific Journal of Tropical Medicine",

issn = "1995-7645",

publisher = "Wolters Kluwer Medknow Publications",

number = "4",

}

TY - JOUR

T1 - Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

AU - Piaru, Suthagar Pillai

AU - Mahmud, Roziahanim

AU - Abdul Majid, Amin Malik Shah

AU - Mahmoud Nassar, Zeyad Daoud

N1 - Funding Information: *Corresponding author: Dr. Roziahanim Mahmud, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. E-mail: [email protected] Foundation project: This project was funded by Universiti Sains Malaysia Research University (RU) Grant (1001/PFARMASI/813021).

PY - 2012/4

Y1 - 2012/4

N2 - Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

AB - Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

KW - Antiangiogenic

KW - Antioxidant

KW - Essential oil

KW - Morinda citrifolia

KW - Myristica fragrans

UR - https://www.scopus.com/pages/publications/84858771097

U2 - 10.1016/S1995-7645(12)60042-X

DO - 10.1016/S1995-7645(12)60042-X

M3 - Article

C2 - 22449521

AN - SCOPUS:84858771097

SN - 1995-7645

VL - 5

SP - 294

EP - 298

JO - Asian Pacific Journal of Tropical Medicine

JF - Asian Pacific Journal of Tropical Medicine

IS - 4

ER -

Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

Abstract

Keywords

ASJC Scopus subject areas

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