Abstract
Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1β-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed.
Original language | English |
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Pages (from-to) | 641-644 |
Number of pages | 4 |
Journal | Human Genetics |
Volume | 95 |
Issue number | 6 |
DOIs | |
Publication status | Published or Issued - Jun 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)