Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms

Sharad Kumar, Deborah White, Setsuo Takai, Suzanne Turczynowicz, Christopher A. Juttner, Timothy Hughes

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1β-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed.

Original languageEnglish
Pages (from-to)641-644
Number of pages4
JournalHuman Genetics
Volume95
Issue number6
DOIs
Publication statusPublished or Issued - Jun 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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