Assessment of human effective absorbed dose of 67 Ga–ECC based on biodistribution rat data

Saeed Shanehsazzadeh, Hassan Yousefnia, Afsaneh Lahooti, Samaneh Zolghadri, Amir Reza Jalilian, Hossien Afarideh

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Methods: For biodistribution data, the animals were sacrificed by CO2 asphyxiation at selected times after injection (0.5, 2 and 48 h, n = 3 for each time interval), then the tissue (blood, heart, lung, brain, intestine, feces, skin, stomach, kidneys, liver, muscle and bone) were removed. The absorbed dose was determined by Medical Internal Radiation Dose (MIRD) method after calculating cumulated activities in each organ.

Objective: In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determined by using distribution data for rats.

Results: Our prediction shows that a 185-MBq injection of 67Ga-ECC into the humans might result in an estimated absorbed dose of 0.029 mGy in the whole body. The highest absorbed doses are observed in the spleen and liver with 33.766 and 16.847 mGy, respectively.

Conclusion: The results show that this radiopharmaceutical can be a good SPECT tracer since it can be produced easily and also the absorbed dose in each organ is less than permitted absorbed dose.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalAnnals of Nuclear Medicine
Issue number2
Publication statusPublished or Issued - 2014


  • Biodistribution
  • Effective absorbed dose
  • Gallium 67-ethylenecysteamine cysteine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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