Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants

Stephanie T. Yerkovich, Julie Rowe, Peter Richmond, Devinda Suriyaarachchi, Tricia Heaton, Elysia Hollams, Claire Ladyman, Michael Serralha, Agata Sadowska, Richard Loh, Steven L. Wesselingh, Peter D. Sly, Patrick G. Holt

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

This study compared the potency and immunomodulatory effects of measles mumps rubella (MMR) vaccine given to infants alone or in combination with varicella (MMR and V). In an additional group, MMR vaccination was delayed 42 days to permit analysis of potential effects on underlying maturation of systemic immune functions. Assessment of immunity to the vaccines indicated consistent antibody production coupled with mixed Th1/Th2 memory, and no significant differences between vaccine groups or to the group who had their MMR vaccination delayed. Parallel analyses of cytokine responses to phytohaemagglutinin and tetanus toxoid did not detect any "bystander" effects of the vaccines on systemic immunity.

Original languageEnglish
Pages (from-to)1764-1770
Number of pages7
JournalVaccine
Volume25
Issue number10
DOIs
Publication statusPublished or Issued - 26 Feb 2007
Externally publishedYes

Keywords

  • Cytokines
  • Infants
  • MMR

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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