Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters

Degui Wang, Yuqiang Huang, Chukai Huang, Pengfei Wu, Jianwei Lin, Yuqian Zheng, Yi Peng, Yuanbo Liang, Jian Huan Chen, Mingzhi Zhang

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32 Citations (Scopus)

Abstract

Background: To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort. Methods. In a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression. Results: In either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P = 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (all P > 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P = 0.009 and 0.003), but no association with VCDR or IOP was observed (P > 0.05). Conclusions: Although cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.

Original languageEnglish
Article number59
JournalBMC Ophthalmology
Volume12
Issue number1
DOIs
Publication statusPublished or Issued - 2012
Externally publishedYes

Keywords

  • Central corneal thickness
  • Cigarette smoking
  • Intraocular pressure
  • Primary open angle glaucoma
  • Vertical cup-to-disc ratio

ASJC Scopus subject areas

  • Ophthalmology

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