TY - JOUR
T1 - Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters
AU - Wang, Degui
AU - Huang, Yuqiang
AU - Huang, Chukai
AU - Wu, Pengfei
AU - Lin, Jianwei
AU - Zheng, Yuqian
AU - Peng, Yi
AU - Liang, Yuanbo
AU - Chen, Jian Huan
AU - Zhang, Mingzhi
N1 - Funding Information:
This study was supported in part by Research Grants 81000397 from the National Natural Science Foundation of China; 8151503102000019 from the Natural Science Foundation of Guangdong Province, China; 2010B031600130 from the Science and Technology Planning Project of Guangdong Province, China; and 10–020, 10–021, and 10–022 from the Joint Shantou International Eye Center, Shantou University/The Chinese University of Hong Kong.
PY - 2012
Y1 - 2012
N2 - Background: To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort. Methods. In a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression. Results: In either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P = 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (all P > 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P = 0.009 and 0.003), but no association with VCDR or IOP was observed (P > 0.05). Conclusions: Although cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.
AB - Background: To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort. Methods. In a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression. Results: In either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P = 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (all P > 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P = 0.009 and 0.003), but no association with VCDR or IOP was observed (P > 0.05). Conclusions: Although cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.
KW - Central corneal thickness
KW - Cigarette smoking
KW - Intraocular pressure
KW - Primary open angle glaucoma
KW - Vertical cup-to-disc ratio
UR - http://www.scopus.com/inward/record.url?scp=84869874502&partnerID=8YFLogxK
U2 - 10.1186/1471-2415-12-59
DO - 10.1186/1471-2415-12-59
M3 - Article
C2 - 23186177
AN - SCOPUS:84869874502
SN - 1471-2415
VL - 12
JO - BMC Ophthalmology
JF - BMC Ophthalmology
IS - 1
M1 - 59
ER -