ATP release from the isolated perfused guinea pig heart in response to increased flow

Amanda J. Vials, Geoffrey Burnstock

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19 Citations (Scopus)


The Langendorff heart preparation was used to investigate the release of ATP from the guinea pig heart in response to increased coronary flow. The luciferin-luciferase firefly technique was used to determine levels of ATP in the perfusate. During periods of increased flow, ATP release was rapidly and significantly increased by at least tenfold the basal release. The pressure/flow ratio was reduced in increased-flowconditions suggesting that coronary vasodilatation had occurred. It is concluded that ATP release from the guinea pig heart is increased under raised-flow conditions. It is suggested that this ATP release induces coronary vasodilatation.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalJournal of Vascular Research
Issue number1
Publication statusPublished or Issued - 1 Jan 1996


  • ATP release
  • Guinea pig heart
  • Increased flow
  • Vascular resistance

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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