Atrial Fibrillation and Heart Failure: Epidemiology, Pathophysiology, Prognosis, and Management

Jonathan P. Ariyaratnam, Dennis H. Lau, Prashanthan Sanders, Jonathan M. Kalman

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


Atrial fibrillation (AF) and heart failure (HF) have similar risk factors, frequently coexist, and potentiate each other in a vicious cycle. Evidence suggests the presence of AF in both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF) increases the risk of all-cause mortality and stroke, particularly when AF is incident. Catheter ablation may be an effective strategy in controlling symptoms and improving quality of life in AF-HFrEF. Strong data guiding management of AF-HFpEF are lacking largely due to its challenging diagnosis. Improving outcomes associated with these coexistent conditions requires further careful investigation.

Original languageEnglish
Pages (from-to)47-62
Number of pages16
JournalCardiac Electrophysiology Clinics
Issue number1
Publication statusPublished or Issued - Mar 2021
Externally publishedYes


  • Atrial fibrillation
  • Heart failure (HF)
  • Heart failure with preserved ejection fraction (HFpEF)
  • Heart failure with reduced ejection fraction (HFrEF)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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