Abstract
We report an unusual case of a 40-year-old female patient with a severe case of direct Coombs positive haemolytic anaemia, moderate hepatomegaly and marked splenomegaly. Her initial response to steroids was transient and was rapidly followed by a relapse. Therefore, she underwent splenectomy both as a therapeutic measure and to rule out an underlying lymphoproliferative disorder. Histopathological examination of the excised spleen, as well a liver biopsy, revealed extensive extramedullary haematopoiesis, while significant marrow fibrosis was noted in a trephine biopsy sample. These findings confirmed the concomitant diagnosis of agnogenic myeloid metaplasia with myelofibrosis.
Original language | English |
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Pages (from-to) | 495-499 |
Number of pages | 5 |
Journal | Haematologia |
Volume | 32 |
Issue number | 4 |
Publication status | Published or Issued - 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Hematology