Automated coronary optical coherence tomography feature extraction with application to three-dimensional reconstruction

Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Jiawen Li, Giuseppe Di Giovanni, Peter J. Psaltis

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Coronary optical coherence tomography (OCT) is an intravascular, near-infrared light-based imaging modality capable of reaching axial resolutions of 10–20 µm. This resolution allows for accurate determination of high-risk plaque features, such as thin cap fibroatheroma; however, visualization of morphological features alone still provides unreliable positive predictive capability for plaque progression or future major adverse cardiovascular events (MACE). Biomechanical simulation could assist in this prediction, but this requires extracting morphological features from intravascular imaging to construct accurate three-dimensional (3D) simulations of patients’ arteries. Extracting these features is a laborious process, often carried out manually by trained experts. To address this challenge, numerous techniques have emerged to automate these processes while simultaneously overcoming difficulties associated with OCT imaging, such as its limited penetration depth. This systematic review summarizes advances in automated segmentation techniques from the past five years (2016–2021) with a focus on their application to the 3D reconstruction of vessels and their subsequent simulation. We discuss four categories based on the feature being processed, namely: coronary lumen; artery layers; plaque characteristics and subtypes; and stents. Areas for future innovation are also discussed as well as their potential for future translation.

Original languageEnglish
Pages (from-to)1307-1349
Number of pages43
Issue number3
Publication statusPublished or Issued - 17 May 2022


  • atherosclerosis
  • biomechanics
  • border detection
  • coronary artery disease
  • optical coherence tomography
  • stents
  • vulnerable plaque

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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