Avascular necrosis of bone in childhood cancer patients: A possible role of genetic susceptibility

L. Geczova; A. Soltysova; J. Gecz; S. Sufliarska; J. Horakova; B. Mladosievicova

doi:10.4149/BLL_2015_055

Avascular necrosis of bone in childhood cancer patients: A possible role of genetic susceptibility

L. Geczova
, A. Soltysova
, J. Gecz
, S. Sufliarska
, J. Horakova
, B. Mladosievicova

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

With the increasing number of paediatric cancer patients and with their prolonged survival, the evidence of a number of serious complications induced by anticancer therapy is rising. Osteonecrosis (ON) of bone is one of these treatment-related effects with a multifactorial pathogenesis. In the past few years, several polymorphisms of candidate genes with possible role in development of this disorder were studied. We summarized potential risk factors leading to increased susceptibility to osteonecrosis of bone development in cancer patients during childhood and to present current knowledge in the field of genetic aspects of this condition (Ref. 86). Text in PDF www.elis.sk.

Original language	English
Pages (from-to)	289-295
Number of pages	7
Journal	Bratislava Medical Journal
Volume	116
Issue number	5
DOIs	https://doi.org/10.4149/BLL_2015_055
Publication status	Published or Issued - 2015
Externally published	Yes

Keywords

Anticancer treatment
Avascular necrosis
Corticosteroids
Genetic determinants
Osteonecrosis
Transplantation

ASJC Scopus subject areas

General Medicine

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10.4149/BLL_2015_055

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title = "Avascular necrosis of bone in childhood cancer patients: A possible role of genetic susceptibility",

abstract = "With the increasing number of paediatric cancer patients and with their prolonged survival, the evidence of a number of serious complications induced by anticancer therapy is rising. Osteonecrosis (ON) of bone is one of these treatment-related effects with a multifactorial pathogenesis. In the past few years, several polymorphisms of candidate genes with possible role in development of this disorder were studied. We summarized potential risk factors leading to increased susceptibility to osteonecrosis of bone development in cancer patients during childhood and to present current knowledge in the field of genetic aspects of this condition (Ref. 86). Text in PDF www.elis.sk.",

keywords = "Anticancer treatment, Avascular necrosis, Corticosteroids, Genetic determinants, Osteonecrosis, Transplantation",

author = "L. Geczova and A. Soltysova and J. Gecz and S. Sufliarska and J. Horakova and B. Mladosievicova",

year = "2015",

doi = "10.4149/BLL\_2015\_055",

language = "English",

volume = "116",

pages = "289--295",

journal = "Bratislava Medical Journal",

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TY - JOUR

T1 - Avascular necrosis of bone in childhood cancer patients

T2 - A possible role of genetic susceptibility

AU - Geczova, L.

AU - Soltysova, A.

AU - Gecz, J.

AU - Sufliarska, S.

AU - Horakova, J.

AU - Mladosievicova, B.

PY - 2015

Y1 - 2015

N2 - With the increasing number of paediatric cancer patients and with their prolonged survival, the evidence of a number of serious complications induced by anticancer therapy is rising. Osteonecrosis (ON) of bone is one of these treatment-related effects with a multifactorial pathogenesis. In the past few years, several polymorphisms of candidate genes with possible role in development of this disorder were studied. We summarized potential risk factors leading to increased susceptibility to osteonecrosis of bone development in cancer patients during childhood and to present current knowledge in the field of genetic aspects of this condition (Ref. 86). Text in PDF www.elis.sk.

AB - With the increasing number of paediatric cancer patients and with their prolonged survival, the evidence of a number of serious complications induced by anticancer therapy is rising. Osteonecrosis (ON) of bone is one of these treatment-related effects with a multifactorial pathogenesis. In the past few years, several polymorphisms of candidate genes with possible role in development of this disorder were studied. We summarized potential risk factors leading to increased susceptibility to osteonecrosis of bone development in cancer patients during childhood and to present current knowledge in the field of genetic aspects of this condition (Ref. 86). Text in PDF www.elis.sk.

KW - Anticancer treatment

KW - Avascular necrosis

KW - Corticosteroids

KW - Genetic determinants

KW - Osteonecrosis

KW - Transplantation

UR - https://www.scopus.com/pages/publications/84928717966

U2 - 10.4149/BLL_2015_055

DO - 10.4149/BLL_2015_055

M3 - Article

C2 - 25924637

AN - SCOPUS:84928717966

SN - 0006-9248

VL - 116

SP - 289

EP - 295

JO - Bratislava Medical Journal

JF - Bratislava Medical Journal

IS - 5

ER -

Avascular necrosis of bone in childhood cancer patients: A possible role of genetic susceptibility

Abstract

Keywords

ASJC Scopus subject areas

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