Axonal and neuronal amyloid precursor protein immunoreactivity in the brains of guinea pigs given tunicamycin

J. W. Finnie; J. Manavis; P. C. Blumbergs; T. R. Kuchel

doi:10.1354/vp.37-6-677

Axonal and neuronal amyloid precursor protein immunoreactivity in the brains of guinea pigs given tunicamycin

J. W. Finnie, J. Manavis, P. C. Blumbergs, T. R. Kuchel

Preclinical Imaging And Research Laboratories

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.

Original language	English
Pages (from-to)	677-680
Number of pages	4
Journal	Veterinary Pathology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1354/vp.37-6-677
Publication status	Published or Issued - Nov 2000

Keywords

Amyloid precursor protein immunohistochemistry
Axonal and neuronal changes
Brain
Guinea pigs
Tunicamycin

ASJC Scopus subject areas

General Veterinary

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10.1354/vp.37-6-677

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abstract = "Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.",

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AB - Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.

KW - Amyloid precursor protein immunohistochemistry

KW - Axonal and neuronal changes

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KW - Guinea pigs

KW - Tunicamycin

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ER -

Axonal and neuronal amyloid precursor protein immunoreactivity in the brains of guinea pigs given tunicamycin

Abstract

Keywords

ASJC Scopus subject areas

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