Abstract
Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.
Original language | English |
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Pages (from-to) | 677-680 |
Number of pages | 4 |
Journal | Veterinary Pathology |
Volume | 37 |
Issue number | 6 |
DOIs | |
Publication status | Published or Issued - Nov 2000 |
Keywords
- Amyloid precursor protein immunohistochemistry
- Axonal and neuronal changes
- Brain
- Guinea pigs
- Tunicamycin
ASJC Scopus subject areas
- General Veterinary