B-cell acute lymphoblastic leukaemia: recent discoveries in molecular pathology, their prognostic significance, and a review of the current classification

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Abstract

Acute lymphoblastic leukaemia (ALL) remains a leading cause of non-traumatic death in children, and the majority of adults diagnosed will succumb to the disease. Recent advances in molecular biology and bioinformatics have enabled more detailed genomic analysis and a better understanding of the molecular biology of ALL. A number of recurrent genomic drivers have recently been described, which not only aid in diagnosis and prognostication, but also may offer opportunities for specific therapeutic targeting. The present review summarises B-ALL genomic pathology at diagnosis, including lesions detectable using traditional cytogenetic methods as well as those detected only through advanced molecular techniques.

Original languageEnglish
Pages (from-to)13-27
Number of pages15
JournalBritish Journal of Haematology
Volume197
Issue number1
DOIs
Publication statusPublished or Issued - Apr 2022

Keywords

  • acute lymphoblastic leukaemia (ALL)
  • acute lymphoblastic leukaemia diagnosis
  • acute lymphoblastic leukaemia genomics
  • acute lymphoblastic leukaemia prognostication
  • molecular pathology

ASJC Scopus subject areas

  • Hematology

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