Biomarkers of inflammation and oxidative stress in atherosclerosis

Kiyoko Uno, Stephen Nicholls

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)


Increasing evidence has highlighted the roles of oxidative stress and inflammation in the promotion of atherosclerotic cardiovascular disease. Recent pathological studies have elucidated specific mediators that appear to link these pathways to the progression and rupture of atherosclerotic plaque in the artery wall. The ability to measure levels of these mediators in the systemic circulation has provoked interest in their development as biomarkers for potential use in risk assessment and in evaluation of the response to the use of preventive therapies. The discovery of these pathological mediators and their potential translation to the clinical arena will be reviewed.

Original languageEnglish
Pages (from-to)361-373
Number of pages13
JournalBiomarkers in Medicine
Issue number3
Publication statusPublished or Issued - 1 Jun 2010


  • Atherosclerosis
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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