Blood Angiotensin II Levels of Normal and Hypertensive Subjects

K. J. Catt; M. D. Cain; P. Z. Zimmet; E. Cran

doi:10.1136/bmj.1.5647.819

Blood Angiotensin II Levels of Normal and Hypertensive Subjects

K. J. Catt, M. D. Cain, P. Z. Zimmet, E. Cran

Research output: Contribution to journal › Letter › peer-review

35 Citations (Scopus)

Abstract

A specific radioimmunoassay for angiotensin II has shown that its normal concentration in arterial blood is 2.4±1.2 (S.D.) mμg./100 ml.; the venous level is consistently below this value, being usually 50–75% of it. Definite rises in blood angiotensin II levels were found in some patients with hypertension, both essential and secondary to renal disease. Extremely low levels were observed in two anephric women, and in one patient with Conn's syndrome. This radioimmunoassay offers a valuable alternative to renin bioassay in evaluation of the role of the renal pressor system in clinical disorders associated with hypertension and aldosteronism.

Original language	English
Pages (from-to)	819-821
Number of pages	3
Journal	British Medical Journal
Volume	1
Issue number	5647
DOIs	https://doi.org/10.1136/bmj.1.5647.819
Publication status	Published or Issued - 29 Mar 1969
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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AU - Catt, K. J.

AU - Cain, M. D.

AU - Zimmet, P. Z.

AU - Cran, E.

PY - 1969/3/29

Y1 - 1969/3/29

N2 - A specific radioimmunoassay for angiotensin II has shown that its normal concentration in arterial blood is 2.4±1.2 (S.D.) mμg./100 ml.; the venous level is consistently below this value, being usually 50–75% of it. Definite rises in blood angiotensin II levels were found in some patients with hypertension, both essential and secondary to renal disease. Extremely low levels were observed in two anephric women, and in one patient with Conn's syndrome. This radioimmunoassay offers a valuable alternative to renin bioassay in evaluation of the role of the renal pressor system in clinical disorders associated with hypertension and aldosteronism.

AB - A specific radioimmunoassay for angiotensin II has shown that its normal concentration in arterial blood is 2.4±1.2 (S.D.) mμg./100 ml.; the venous level is consistently below this value, being usually 50–75% of it. Definite rises in blood angiotensin II levels were found in some patients with hypertension, both essential and secondary to renal disease. Extremely low levels were observed in two anephric women, and in one patient with Conn's syndrome. This radioimmunoassay offers a valuable alternative to renin bioassay in evaluation of the role of the renal pressor system in clinical disorders associated with hypertension and aldosteronism.

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JO - British Medical Journal

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ER -

Blood Angiotensin II Levels of Normal and Hypertensive Subjects

Abstract

ASJC Scopus subject areas

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