TY - JOUR
T1 - Breakthrough SARS-CoV-2 infections after vaccination
T2 - a critical review
AU - Mohseni Afshar, Zeinab
AU - Barary, Mohammad
AU - Hosseinzadeh, Rezvan
AU - Alijanpour, Amirmasoud
AU - Hosseinzadeh, Dariush
AU - Ebrahimpour, Soheil
AU - Nazary, Kosar
AU - Sio, Terence T.
AU - Sullman, Mark J.M.
AU - Carson-Chahhoud, Kristin
AU - Babazadeh, Arefeh
N1 - Funding Information:
The author(s) reported there is no funding associated with the work featured in this article. The authors would like to thank the Clinical Research Development Center of Imam Reza Hospital, Kermanshah University of Medical Sciences, and the Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, for their kind support.
Publisher Copyright:
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.
AB - At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.
KW - COVID-19
KW - SARS-CoV-2
KW - breakthrough
KW - immunization
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85126785867&partnerID=8YFLogxK
U2 - 10.1080/21645515.2022.2051412
DO - 10.1080/21645515.2022.2051412
M3 - Review article
C2 - 35302905
AN - SCOPUS:85126785867
VL - 18
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
SN - 2164-5515
IS - 5
M1 - 2051412
ER -