TY - JOUR
T1 - Breastfeeding and infant growth in offspring of mothers with hyperglycaemia in pregnancy
T2 - The pregnancy and neonatal diabetes outcomes in remote Australia study
AU - Longmore, Danielle K.
AU - Titmuss, Angela
AU - Barr, Elizabeth
AU - Barzi, Federica
AU - Simmonds, Alison
AU - Lee, I. Lynn
AU - Hawthorne, Eyvette
AU - Derkenne, Ruth
AU - Connors, Christine
AU - Boyle, Jacqueline
AU - Zimmet, Paul
AU - O'Dea, Kerin
AU - Oats, Jeremy
AU - McIntyre, Harold D.
AU - Brown, Alex
AU - Shaw, Jonathan
AU - Maple-Brown, Louise J.
N1 - Funding Information:
We gratefully acknowledge all PANDORA participants and staff including S. Svenson, L. Davis and V. Hampton, in addition to the NT DIP investigators, Indigenous Reference Group, Clinical Reference Group, NT health professionals from NT department of health hospitals, remote primary healthcare, Healthy Living NT and Aboriginal Community Controlled Health Organisations. NT DIP investigators in addition to those listed as author include E. Moore, G. Dent, M. Stone, M. Harris, C. Inglis, K. Dempsey, S. Thomas, S. Chitturi, S. Eades, S. Corpus, M. Lynch and Z. Lu.
Funding Information:
The PANDORA study was funded by National Health and Medical Research Council of Australia (NHMRC Partnership Project Grant #1032116, NHMRC #1078333). DKL was supported by an NHMRC scholarship (#1038372) and LJMB was supported by an NHMRC fellowship (#605837) and NHMRC Practitioner fellowship (#1078477). ELMB was supported by a National Heart Foundation post‐doctoral fellowship (#101291). ILL was supported by an Australian Postgraduate award and Menzies scholarship. ADHB was supported by an NHMRC Senior Research fellowship (#1137563) and a Sylvia and Charles Viertel Senior Medical Research fellowship. JES was supported by an NHMRC fellowship (#1079438). This paper reflects the views of the authors and not the NHMRC. Funding information
PY - 2022
Y1 - 2022
N2 - Background: Benefits of breastfeeding on infant growth in children born to mothers with gestational diabetes mellitus (GDM) are uncertain. Objectives: To describe growth trajectories between birth and 14 months according to breastfeeding and maternal hyperglycaemia in pregnancy, and assess associations between breastfeeding and 14 month growth outcomes among children born to mothers with GDM. Subjects/methods: Data on 258 Aboriginal and Torres Strait Islander infants from the PANDORA study born to mothers with normoglycaemia (n = 73), GDM (n = 122), or with pre-existing type 2 diabetes (n = 63) in pregnancy were assessed. Infant weight and BMI growth trajectories according to predominant breastfeeding at 6 months and hyperglycaemia in pregnancy were developed using mixed-effect models and cubic splines. Associations between breastfeeding and 14-month growth outcomes (z-scores: weight-for-age, weight-for-length and BMI) were evaluated using linear regression in a subgroup of infants born to mothers with GDM. Results: Predominantly breastfed infants had lower BMI trajectories compared to those not predominantly breastfed, irrespective of maternal hyperglycaemia in pregnancy status (p < 0.01 for all groups), and lower weight trajectories among those born to mothers with GDM (p = 0.006). Among offspring of women with GDM, predominant breastfeeding was only associated with lower weight-for-age at 14 months, however adjusting for maternal obesity, smoking, and parity attenuated observed associations. Maternal obesity remained significantly associated with greater infant growth. Conclusions: Predominant breastfeeding was associated with reduced growth among children born to women with and without hyperglycaemia in pregnancy. However, among children exposed to GDM in utero, maternal obesity largely explained this association.
AB - Background: Benefits of breastfeeding on infant growth in children born to mothers with gestational diabetes mellitus (GDM) are uncertain. Objectives: To describe growth trajectories between birth and 14 months according to breastfeeding and maternal hyperglycaemia in pregnancy, and assess associations between breastfeeding and 14 month growth outcomes among children born to mothers with GDM. Subjects/methods: Data on 258 Aboriginal and Torres Strait Islander infants from the PANDORA study born to mothers with normoglycaemia (n = 73), GDM (n = 122), or with pre-existing type 2 diabetes (n = 63) in pregnancy were assessed. Infant weight and BMI growth trajectories according to predominant breastfeeding at 6 months and hyperglycaemia in pregnancy were developed using mixed-effect models and cubic splines. Associations between breastfeeding and 14-month growth outcomes (z-scores: weight-for-age, weight-for-length and BMI) were evaluated using linear regression in a subgroup of infants born to mothers with GDM. Results: Predominantly breastfed infants had lower BMI trajectories compared to those not predominantly breastfed, irrespective of maternal hyperglycaemia in pregnancy status (p < 0.01 for all groups), and lower weight trajectories among those born to mothers with GDM (p = 0.006). Among offspring of women with GDM, predominant breastfeeding was only associated with lower weight-for-age at 14 months, however adjusting for maternal obesity, smoking, and parity attenuated observed associations. Maternal obesity remained significantly associated with greater infant growth. Conclusions: Predominant breastfeeding was associated with reduced growth among children born to women with and without hyperglycaemia in pregnancy. However, among children exposed to GDM in utero, maternal obesity largely explained this association.
UR - http://www.scopus.com/inward/record.url?scp=85124820373&partnerID=8YFLogxK
U2 - 10.1111/ijpo.12891
DO - 10.1111/ijpo.12891
M3 - Article
AN - SCOPUS:85124820373
VL - 17
JO - Pediatric Obesity
JF - Pediatric Obesity
SN - 2047-6302
IS - 6
M1 - e12891
ER -