Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus

Alicia Irurzun; Luis Pérez; Luis Carrasco

doi:10.1016/0014-5793(93)80863-P

Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus

Alicia Irurzun, Luis Pérez, Luis Carrasco

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Brefeldin A is a macrolide antibiotic that interferes with membrane traffic and blocks the growth of several animal viruses including vesicular stomatitis virus (VSV). The inhibition of VSV by brefeldin A takes place at least at two different steps during the growth cycle: the glycosylation of VSV G protein and the replication of viral genomes. Our results indicate that interference with membrane traffic leads not only to inhibition of viral protein glycosylation, but also to the blockade of virus genome replication in several cytoplasmic RNA-containing viruses.

Original language	English
Pages (from-to)	496-500
Number of pages	5
Journal	FEBS Letters
Volume	336
Issue number	3
DOIs	https://doi.org/10.1016/0014-5793(93)80863-P
Publication status	Published or Issued - 28 Dec 1993
Externally published	Yes

Keywords

Brefeldin A
Protein glycosylation
RNA replication
Vesicular stomatitis virus

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(93)80863-P

Cite this

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title = "Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus",

abstract = "Brefeldin A is a macrolide antibiotic that interferes with membrane traffic and blocks the growth of several animal viruses including vesicular stomatitis virus (VSV). The inhibition of VSV by brefeldin A takes place at least at two different steps during the growth cycle: the glycosylation of VSV G protein and the replication of viral genomes. Our results indicate that interference with membrane traffic leads not only to inhibition of viral protein glycosylation, but also to the blockade of virus genome replication in several cytoplasmic RNA-containing viruses.",

keywords = "Brefeldin A, Protein glycosylation, RNA replication, Vesicular stomatitis virus",

author = "Alicia Irurzun and Luis P{\'e}rez and Luis Carrasco",

year = "1993",

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day = "28",

doi = "10.1016/0014-5793(93)80863-P",

language = "English",

volume = "336",

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journal = "FEBS Letters",

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TY - JOUR

T1 - Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus

AU - Irurzun, Alicia

AU - Pérez, Luis

AU - Carrasco, Luis

PY - 1993/12/28

Y1 - 1993/12/28

N2 - Brefeldin A is a macrolide antibiotic that interferes with membrane traffic and blocks the growth of several animal viruses including vesicular stomatitis virus (VSV). The inhibition of VSV by brefeldin A takes place at least at two different steps during the growth cycle: the glycosylation of VSV G protein and the replication of viral genomes. Our results indicate that interference with membrane traffic leads not only to inhibition of viral protein glycosylation, but also to the blockade of virus genome replication in several cytoplasmic RNA-containing viruses.

AB - Brefeldin A is a macrolide antibiotic that interferes with membrane traffic and blocks the growth of several animal viruses including vesicular stomatitis virus (VSV). The inhibition of VSV by brefeldin A takes place at least at two different steps during the growth cycle: the glycosylation of VSV G protein and the replication of viral genomes. Our results indicate that interference with membrane traffic leads not only to inhibition of viral protein glycosylation, but also to the blockade of virus genome replication in several cytoplasmic RNA-containing viruses.

KW - Brefeldin A

KW - Protein glycosylation

KW - RNA replication

KW - Vesicular stomatitis virus

UR - http://www.scopus.com/inward/record.url?scp=0027718055&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(93)80863-P

DO - 10.1016/0014-5793(93)80863-P

M3 - Article

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AN - SCOPUS:0027718055

SN - 0014-5793

VL - 336

SP - 496

EP - 500

JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus

Abstract

Keywords

ASJC Scopus subject areas

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