Caveola-forming proteins caveolin-1 and PTRF in prostate cancer

Zeyad D. Nassar, Michelle M. Hill, Robert G. Parton, Marie Odile Parat

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)

Abstract

The expression of caveola-forming proteins is dysregulated in prostate cancer. Caveolae are flask-shaped invaginations of the plasma membrane that have roles in membrane trafficking and cell signalling. Members of two families of proteins - caveolins and cavins - are known to be required for the formation and functions of caveolae. Caveolin-1, the major structural protein of caveolae, is overexpresssed in prostate cancer and has been demonstrated to be involved in prostate cancer angiogenesis, growth and metastasis. Polymerase I and transcript release factor (PTRF) is the only cavin family member necessary for caveola formation. When exogenously expressed in prostate cancer cells, PTRF reduces aggressive potential, probably via both caveola-mediated and caveola-independent mechanisms. In addition, stromal PTRF expression decreases with progression of the disease. Evaluation of caveolin-1 antibodies in the clinical setting is underway and it is hoped that future studies will reveal the mechanisms of PTRF action, allowing its targeting for therapeutic purposes.

Original languageEnglish
Pages (from-to)529-536
Number of pages8
JournalNature Reviews Urology
Volume10
Issue number9
DOIs
Publication statusPublished or Issued - 1 Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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