Cavin Family: New Players in the Biology of Caveolae

Zeyad D. Nassar, Marie Odile Parat

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

36 Citations (Scopus)


Caveolae are specialized small plasma-membrane invaginations that play crucial cellular functions. Two essential protein families are required for caveola formation: membrane caveolin proteins and cytoplasmic cavin proteins. Each family includes members with specific tissue distribution, and their expression is altered under. physiological and pathological conditions, implying highly specialized functions. Cavins not only stabilize caveolae, but modulate their morphology and functions as well. Before association with the plasma membrane, cavins form homo- and hetero-oligomers with strikingly strict stoichiometry in the cytosol. At the plasma membrane, they provide an outer peripheral cytosolic layer, necessary for caveola stability. Interestingly, upon stimulation, cavins can be released from caveolae into the cytoplasm in distinct subcomplexes, providing a rapid dynamic link between caveolae and cellular organelles including the nucleus. In this review, we detail the biology of cavins, their structural and functional roles, and their implication in pathophysiology.

Original languageEnglish
Title of host publicationInternational Review of Cell and Molecular Biology, 2015
EditorsKwang W. Jeon
PublisherElsevier Inc.
Number of pages71
ISBN (Print)9780128022771
Publication statusPublished or Issued - 2015
Externally publishedYes

Publication series

NameInternational Review of Cell and Molecular Biology
ISSN (Print)1937-6448


  • Caveolae
  • Caveolin-1
  • Cavin
  • MURC
  • PTRF
  • SDPR
  • SRBC

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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