Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells

Wenru Pan, Karlea L. Kremer, Xenia Kaidonis, Victoria E. Ludlow, Mary Louise Rogers, Jianling Xie, Christopher G. Proud, Simon A. Koblar

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16 Citations (Scopus)


Human adult dental pulp stem cells (DPSC) are a heterogeneous stem cell population, which are able to differentiate down neural, chondrocyte, osteocyte and adipocyte lineages. We studied the expression pattern of p75 neurotrophin receptors (p75NTR), a marker of neural stem cells, within human DPSC populations from eight donors. p75NTR are expressed at low levels (<10%) in DPSC. Importantly, p75+ DPSC represent higher expression levels of SOX1 (neural precursor cell marker), SOX2 (cell pluripotency marker) and nestin (neural stem cell marker) in comparison to p75 DPSC. Our results suggest that p75+ hDPSC may denote a subpopulation with greater neurogenic potential.

Original languageEnglish
Pages (from-to)90-98
Number of pages9
JournalInternational Journal of Developmental Neuroscience
Publication statusPublished or Issued - 1 Oct 2016


  • Dental pulp stem cells
  • Neural crest stem cells
  • SOX2
  • SOX9
  • p75 Neurotrophin receptor

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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