Chromosomal localization of ARSB, the gene for human N-acetylgalactosamine-4-sulphatase

Tom Litjens; Elizabeth G. Baker; Kerri R. Beckmann; C. Phillip Morris; John J. Hopwood; David F. Callen

doi:10.1007/BF00288275

Chromosomal localization of ARSB, the gene for human N-acetylgalactosamine-4-sulphatase

Tom Litjens, Elizabeth G. Baker, Kerri R. Beckmann, C. Phillip Morris, John J. Hopwood, David F. Callen

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

A deficiency of N-acetylgalactosamine-4-sulphatase (G4S, gene symbol ARSB), results in the accumulation of undegraded substrate and the lysosomal storage disorder, Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). In situ hybridization using an ³H-labelled human G4S genomic DNA fragment to human metaphase chromosomes localized ARSB to chromosome 5q13-5q14. This location is consistent with, an refines, previous chromosomal assignments based on the expression of human G4S in somatic cell hybrids.

Original language	English
Pages (from-to)	67-68
Number of pages	2
Journal	Human Genetics
Volume	82
Issue number	1
DOIs	https://doi.org/10.1007/BF00288275
Publication status	Published or Issued - Apr 1989
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Chromosomal localization of ARSB, the gene for human N-acetylgalactosamine-4-sulphatase",

abstract = "A deficiency of N-acetylgalactosamine-4-sulphatase (G4S, gene symbol ARSB), results in the accumulation of undegraded substrate and the lysosomal storage disorder, Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). In situ hybridization using an 3H-labelled human G4S genomic DNA fragment to human metaphase chromosomes localized ARSB to chromosome 5q13-5q14. This location is consistent with, an refines, previous chromosomal assignments based on the expression of human G4S in somatic cell hybrids.",

author = "Tom Litjens and Baker, \{Elizabeth G.\} and Beckmann, \{Kerri R.\} and Morris, \{C. Phillip\} and Hopwood, \{John J.\} and Callen, \{David F.\}",

year = "1989",

month = apr,

doi = "10.1007/BF00288275",

language = "English",

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T1 - Chromosomal localization of ARSB, the gene for human N-acetylgalactosamine-4-sulphatase

AU - Litjens, Tom

AU - Baker, Elizabeth G.

AU - Beckmann, Kerri R.

AU - Morris, C. Phillip

AU - Hopwood, John J.

AU - Callen, David F.

PY - 1989/4

Y1 - 1989/4

N2 - A deficiency of N-acetylgalactosamine-4-sulphatase (G4S, gene symbol ARSB), results in the accumulation of undegraded substrate and the lysosomal storage disorder, Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). In situ hybridization using an 3H-labelled human G4S genomic DNA fragment to human metaphase chromosomes localized ARSB to chromosome 5q13-5q14. This location is consistent with, an refines, previous chromosomal assignments based on the expression of human G4S in somatic cell hybrids.

AB - A deficiency of N-acetylgalactosamine-4-sulphatase (G4S, gene symbol ARSB), results in the accumulation of undegraded substrate and the lysosomal storage disorder, Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). In situ hybridization using an 3H-labelled human G4S genomic DNA fragment to human metaphase chromosomes localized ARSB to chromosome 5q13-5q14. This location is consistent with, an refines, previous chromosomal assignments based on the expression of human G4S in somatic cell hybrids.

UR - https://www.scopus.com/pages/publications/0024573535

U2 - 10.1007/BF00288275

DO - 10.1007/BF00288275

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AN - SCOPUS:0024573535

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JO - Human Genetics

JF - Human Genetics

IS - 1

ER -

Chromosomal localization of ARSB, the gene for human N-acetylgalactosamine-4-sulphatase

Abstract

ASJC Scopus subject areas

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