Chronic benign neutropenia of infancy associated with asymptomatic cytomegalovirus infection

L. A. Perez-Jurado; L. Madero; P. Robles; S. Candela; V. Garcia-de Casasola

Chronic benign neutropenia of infancy associated with asymptomatic cytomegalovirus infection

L. A. Perez-Jurado, L. Madero, P. Robles, S. Candela, V. Garcia-de Casasola

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Abstract

A 7-month-old infant with chronic benign neutropenia and hyperlymphocytosis is reported. The neutrophil count ranged between 320 and 810/mm³ during the first 6 weeks of study. The lymphocyte subpopulations showed a relative increase in the B cell count (33%) and a low T4/T8 ratio (0.78). Leukoagglutinins were not demonstrated. He was found to have an asymptomatic cytomegaloviral infection by culturing the virus from his urine. Before a surgical procedure, he was treated with endovenous immunoglublin showing a temporary reversal of neutropenia (up to 10 000 neutrophils/mm³) as well as an increase in the T4/T8 ratio (1.50). Because of the therapeutic response to the immunoglobulin, an immunopathogenia mechanism for neutropenia is proposed, being cytomegalovirus the possible etiologic agent.

Original language	English
Pages (from-to)	359-362
Number of pages	4
Journal	International Pediatrics
Volume	6
Issue number	4
Publication status	Published or Issued - 1991

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

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title = "Chronic benign neutropenia of infancy associated with asymptomatic cytomegalovirus infection",

abstract = "A 7-month-old infant with chronic benign neutropenia and hyperlymphocytosis is reported. The neutrophil count ranged between 320 and 810/mm3 during the first 6 weeks of study. The lymphocyte subpopulations showed a relative increase in the B cell count (33%) and a low T4/T8 ratio (0.78). Leukoagglutinins were not demonstrated. He was found to have an asymptomatic cytomegaloviral infection by culturing the virus from his urine. Before a surgical procedure, he was treated with endovenous immunoglublin showing a temporary reversal of neutropenia (up to 10 000 neutrophils/mm3) as well as an increase in the T4/T8 ratio (1.50). Because of the therapeutic response to the immunoglobulin, an immunopathogenia mechanism for neutropenia is proposed, being cytomegalovirus the possible etiologic agent.",

author = "Perez-Jurado, {L. A.} and L. Madero and P. Robles and S. Candela and {Garcia-de Casasola}, V.",

year = "1991",

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T1 - Chronic benign neutropenia of infancy associated with asymptomatic cytomegalovirus infection

AU - Perez-Jurado, L. A.

AU - Madero, L.

AU - Robles, P.

AU - Candela, S.

AU - Garcia-de Casasola, V.

PY - 1991

Y1 - 1991

N2 - A 7-month-old infant with chronic benign neutropenia and hyperlymphocytosis is reported. The neutrophil count ranged between 320 and 810/mm3 during the first 6 weeks of study. The lymphocyte subpopulations showed a relative increase in the B cell count (33%) and a low T4/T8 ratio (0.78). Leukoagglutinins were not demonstrated. He was found to have an asymptomatic cytomegaloviral infection by culturing the virus from his urine. Before a surgical procedure, he was treated with endovenous immunoglublin showing a temporary reversal of neutropenia (up to 10 000 neutrophils/mm3) as well as an increase in the T4/T8 ratio (1.50). Because of the therapeutic response to the immunoglobulin, an immunopathogenia mechanism for neutropenia is proposed, being cytomegalovirus the possible etiologic agent.

AB - A 7-month-old infant with chronic benign neutropenia and hyperlymphocytosis is reported. The neutrophil count ranged between 320 and 810/mm3 during the first 6 weeks of study. The lymphocyte subpopulations showed a relative increase in the B cell count (33%) and a low T4/T8 ratio (0.78). Leukoagglutinins were not demonstrated. He was found to have an asymptomatic cytomegaloviral infection by culturing the virus from his urine. Before a surgical procedure, he was treated with endovenous immunoglublin showing a temporary reversal of neutropenia (up to 10 000 neutrophils/mm3) as well as an increase in the T4/T8 ratio (1.50). Because of the therapeutic response to the immunoglobulin, an immunopathogenia mechanism for neutropenia is proposed, being cytomegalovirus the possible etiologic agent.

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Chronic benign neutropenia of infancy associated with asymptomatic cytomegalovirus infection

Abstract

ASJC Scopus subject areas

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