Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort

K. R. Beckmann; J. Buckingham; P. Craft; J. E. Dahlstrom; Y. Zhang; D. Roder; R. Stuart-Harris

doi:10.1016/j.breast.2010.10.004

Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort

K. R. Beckmann, J. Buckingham, P. Craft, J. E. Dahlstrom, Y. Zhang, D. Roder, R. Stuart-Harris

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.

Original language	English
Pages (from-to)	158-164
Number of pages	7
Journal	Breast
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.breast.2010.10.004
Publication status	Published or Issued - Apr 2011
Externally published	Yes

Keywords

Bilateral
Breast neoplasm
Epidemiology
Survival

ASJC Scopus subject areas

Surgery
Oncology
Cancer Research

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10.1016/j.breast.2010.10.004

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@article{3ad32d45c1fd4c97a31a0efbcd890c1e,

title = "Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort",

abstract = "Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79\%, 88\% and 94\%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.",

keywords = "Bilateral, Breast neoplasm, Epidemiology, Survival",

author = "Beckmann, \{K. R.\} and J. Buckingham and P. Craft and Dahlstrom, \{J. E.\} and Y. Zhang and D. Roder and R. Stuart-Harris",

note = "Funding Information: Funding for the ACT and SE NSW Breast Cancer Treatment Group Quality Assurance Project has been provided by ACT Health and Bosom Buddies ACT. The authors wish to thank the women who have participated in the project over the past decade and the clinicians who have provided data for the Audit. ",

year = "2011",

month = apr,

doi = "10.1016/j.breast.2010.10.004",

language = "English",

volume = "20",

pages = "158--164",

journal = "Breast",

issn = "0960-9776",

publisher = "Churchill Livingstone",

number = "2",

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TY - JOUR

T1 - Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort

AU - Beckmann, K. R.

AU - Buckingham, J.

AU - Craft, P.

AU - Dahlstrom, J. E.

AU - Zhang, Y.

AU - Roder, D.

AU - Stuart-Harris, R.

N1 - Funding Information: Funding for the ACT and SE NSW Breast Cancer Treatment Group Quality Assurance Project has been provided by ACT Health and Bosom Buddies ACT. The authors wish to thank the women who have participated in the project over the past decade and the clinicians who have provided data for the Audit.

PY - 2011/4

Y1 - 2011/4

N2 - Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.

AB - Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.

KW - Bilateral

KW - Breast neoplasm

KW - Epidemiology

KW - Survival

UR - https://www.scopus.com/pages/publications/79952627099

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DO - 10.1016/j.breast.2010.10.004

M3 - Article

C2 - 21093260

AN - SCOPUS:79952627099

SN - 0960-9776

VL - 20

SP - 158

EP - 164

JO - Breast

JF - Breast

IS - 2

ER -

Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort

Abstract

Keywords

ASJC Scopus subject areas

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