TY - JOUR
T1 - Clinical characteristics and risk factors of cardiac involvement in covid-19
AU - Xu, Huayan
AU - Hou, Keke
AU - Xu, Rong
AU - Li, Zhenlin
AU - Fu, Hang
AU - Wen, Lingyi
AU - Xie, Linjun
AU - Liu, Hui
AU - Selvanayagam, Joseph B.
AU - Zhang, Na
AU - Yang, Zhigang
AU - Yang, Ming
AU - Guo, Yingkun
N1 - Funding Information:
This work was supported by 2020 Novel Coronavirus Pneumonia Prevention and Control Technology Project of Chengdu (No. 2020-YF05-00007-SN); Clinical Research Finding of Chinese Society of Cardiovascular Disease (CSC) of 2019 (No. HFCSC2019B01); the National Natural Science Foundation of China (No. 81771887, 81771897, 81971586, 81901712); the Program for Young Scholars and Innovative Research Team in Sichuan Province (No. 2017TD0005) of China; and the 1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (No. ZYGD18013).
Publisher Copyright:
© 2020 The Authors.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Increasing studies demonstrated that the cardiac involvements are related to coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical characteristics of patients with COVID-19 and further determined the risk factors for cardiac involvement in them. METHODS AND RESULTS: We analyzed data from 102 consecutive laboratory-confirmed and hospitalized patients with COVID-19 (52 women aged 19–87 years). Epidemiologic and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, chest imaging findings, management methods, and clinical outcomes were collected. Patients were divided into acute cardiac injury, with and without cardiac marker ab-normities groups according to different level of cardiac markers. In this research, cardiac involvement was found in 72 of the 102 (70.6%) patients: tachycardia (n=20), electrocardiography abnormalities (n=23), echocardiography abnormalities (n=59), elevated myocardial enzymes (n=55), and acute cardiac injury (n=9). Eight patients with acute cardiac injury were aged >60 years; seven of them had ≥2 underlying comorbidities (hypertension, diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, and chronic kidney disease). Novel coronavirus pneumonia was much more severe in the patients with acute cardiac injury than in patients with nondefinite acute cardiac injury (P<0.001). Multivariate analyses showed that CRP (C-reactive protein) levels, old age, novel coronavirus pneumonia severity, and underlying comorbidities were the risk factors for cardiac abnormalities in patients with COVID-19. CONCLUSIONS: Cardiac involvements are common in patients with COVID-19. Elevated CRP levels, old age, underlying comor-bidities, and novel coronavirus pneumonia severity are the main risk factors for cardiac involvement in patients with COVID-19. More attention should be given to cardiovascular protection during COVID-19 treatment for mortality reduction. REGISTRATION: URL: https://www.chictr.org; Unique identifier: ChiCTR2000029955.
AB - BACKGROUND: Increasing studies demonstrated that the cardiac involvements are related to coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical characteristics of patients with COVID-19 and further determined the risk factors for cardiac involvement in them. METHODS AND RESULTS: We analyzed data from 102 consecutive laboratory-confirmed and hospitalized patients with COVID-19 (52 women aged 19–87 years). Epidemiologic and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, chest imaging findings, management methods, and clinical outcomes were collected. Patients were divided into acute cardiac injury, with and without cardiac marker ab-normities groups according to different level of cardiac markers. In this research, cardiac involvement was found in 72 of the 102 (70.6%) patients: tachycardia (n=20), electrocardiography abnormalities (n=23), echocardiography abnormalities (n=59), elevated myocardial enzymes (n=55), and acute cardiac injury (n=9). Eight patients with acute cardiac injury were aged >60 years; seven of them had ≥2 underlying comorbidities (hypertension, diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, and chronic kidney disease). Novel coronavirus pneumonia was much more severe in the patients with acute cardiac injury than in patients with nondefinite acute cardiac injury (P<0.001). Multivariate analyses showed that CRP (C-reactive protein) levels, old age, novel coronavirus pneumonia severity, and underlying comorbidities were the risk factors for cardiac abnormalities in patients with COVID-19. CONCLUSIONS: Cardiac involvements are common in patients with COVID-19. Elevated CRP levels, old age, underlying comor-bidities, and novel coronavirus pneumonia severity are the main risk factors for cardiac involvement in patients with COVID-19. More attention should be given to cardiovascular protection during COVID-19 treatment for mortality reduction. REGISTRATION: URL: https://www.chictr.org; Unique identifier: ChiCTR2000029955.
KW - Acute cardiac injury
KW - COVID-19
KW - Cardiac involvement
KW - Risk factor
UR - http://www.scopus.com/inward/record.url?scp=85091126200&partnerID=8YFLogxK
U2 - 10.1161/JAHA.120.016807
DO - 10.1161/JAHA.120.016807
M3 - Article
C2 - 32806998
AN - SCOPUS:85091126200
VL - 9
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 18
M1 - e016807
ER -