Clonidine premedication for postoperative analgesia in children: A meta-analysis

P Middleton, Paul Lambert, Nicholas Knight, A. M. Cyna

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Introduction: Postoperative pain is a significant problem in paediatric surgery. Inadequate analgesia increases patient distress in the short term and may have long-term adverse effects. The alpha-2 adrenergic agonist, clonidine, has been used as a premedication for anxiolysis, sedation, analgesia and reduction of heart rate and blood pressure. However, its use can result in excessive sedation, hypotension and bradycardia1. The overall benefits of clonidine as a premedication over other commonly used drugs, such as midazolam, have in recent years been the subject of review2 and meta-analysis3. This systematic review aims to evaluate the postoperative analgesia effects of clonidine premedication when compared to any other treatment, placebo or usual care. Methods: This study was conducted according to Cochrane methodology. We searched for randomised or quasi-randomised controlled trials of children
Original languageEnglish
Title of host publicationAnaesthesia and intensive care
Number of pages1
Publication statusPublished or Issued - 2011

Publication series

NameAnaesthesia and intensive care


  • Hong Kong
  • New Zealand
  • adverse drug reaction
  • alpha 2 adrenergic receptor stimulating agent
  • analgesia
  • anesthesia
  • blood pressure
  • child
  • clonidine
  • college
  • confidence interval
  • data base
  • fentanyl
  • general anesthesia
  • heart rate
  • hospital
  • human
  • hypotension
  • meta analysis
  • meta analysis (topic)
  • methodology
  • midazolam
  • model
  • opiate
  • pain
  • patient
  • placebo
  • postoperative analgesia
  • postoperative pain
  • premedication
  • randomized controlled trial
  • sedation
  • surgery
  • systematic review
  • systematic review (topic)
  • tranquilizing activity

ASJC Scopus subject areas

  • Medicine(all)

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