@inbook{829c90064fce44c0ae687cc1eca5eb73,
title = "Clonidine premedication for postoperative analgesia in children: A meta-analysis",
abstract = "Introduction: Postoperative pain is a significant problem in paediatric surgery. Inadequate analgesia increases patient distress in the short term and may have long-term adverse effects. The alpha-2 adrenergic agonist, clonidine, has been used as a premedication for anxiolysis, sedation, analgesia and reduction of heart rate and blood pressure. However, its use can result in excessive sedation, hypotension and bradycardia1. The overall benefits of clonidine as a premedication over other commonly used drugs, such as midazolam, have in recent years been the subject of review2 and meta-analysis3. This systematic review aims to evaluate the postoperative analgesia effects of clonidine premedication when compared to any other treatment, placebo or usual care. Methods: This study was conducted according to Cochrane methodology. We searched for randomised or quasi-randomised controlled trials of children ",
keywords = "Hong Kong, New Zealand, adverse drug reaction, alpha 2 adrenergic receptor stimulating agent, analgesia, anesthesia, blood pressure, child, clonidine, college, confidence interval, data base, fentanyl, general anesthesia, heart rate, hospital, human, hypotension, meta analysis, meta analysis (topic), methodology, midazolam, model, opiate, pain, patient, placebo, postoperative analgesia, postoperative pain, premedication, randomized controlled trial, sedation, surgery, systematic review, systematic review (topic), tranquilizing activity",
author = "P Middleton and Paul Lambert and Nicholas Knight and Cyna, {A. M.}",
year = "2011",
language = "English",
isbn = "0310-057X",
series = "Anaesthesia and intensive care",
pages = "714",
booktitle = "Anaesthesia and intensive care",
}