TY - JOUR
T1 - Comparing effects of a low-energy diet and a high-protein low-fat diet on sexual and endothelial function, urinary tract symptoms, and inflammation in obese diabetic men
AU - Khoo, Joan
AU - Piantadosi, Cynthia
AU - Duncan, Rae
AU - Worthley, Stephen G.
AU - Jenkins, Alicia
AU - Noakes, Manny
AU - Worthley, Matthew I.
AU - Lange, Kylie
AU - Wittert, Gary A.
N1 - Funding Information:
Funding for this study was provided by the National Heart Foundation and the Medical Benefits Foundation of Australia. Kicstart was supplied by Pharmacy Health Solutions Pty Ltd, who had no role in the design, implementation, or analysis of the study.
PY - 2011/10
Y1 - 2011/10
N2 - Introduction. Abdominal obesity and type 2 diabetes mellitus are associated with sexual and endothelial dysfunction, lower urinary tract symptoms (LUTS), and chronic systemic inflammation. Aim. To determine the effects of diet-induced weight loss and maintenance on sexual and endothelial function, LUTS, and inflammatory markers in obese diabetic men. Main Outcome Measures. Weight, waist circumference (WC), International Index of Erectile Function (IIEF-5) score, Sexual Desire Inventory (SDI) score, International Prostate Symptom Scale (IPSS) score, plasma fasting glucose and lipids, testosterone, sex hormone binding globulin (SHBG), inflammatory markers (high-sensitivity C-reactive protein [CRP] and interleukin-6 [IL-6]) and soluble E-selectin, and brachial artery flow-mediated dilatation (FMD) were measured at baseline, 8 weeks, and 52 weeks. Methods. Over 8 weeks, 31 abdominally obese (body mass index≥30kg/m2, WC≥102cm), type 2 diabetic men (mean age 59.7 years) received either a meal replacement-based low-calorie diet (LCD) ∼1,000kcal/day (N=19) or low-fat, high-protein, reduced-carbohydrate (HP) diet (N=12) prescribed to decrease intake by ∼600kcal/day. Subjects continued on, or were switched to, the HP diet for another 44 weeks. Results. At 8 weeks, weight and WC decreased by ∼10% and ∼5% with the LCD and HP diet, respectively. Both diets significantly improved plasma glucose, low-density lipoprotein (LDL), SHBG, IIEF-5, SDI and IPSS scores, and endothelial function (increased FMD, reduced soluble E-selectin). Erectile function, sexual desire, and urinary symptoms improved by a similar degree with both diets. CRP and IL-6 decreased with the HP diet. At 52 weeks, reductions in weight, WC, and CRP were maintained. IIEF-5, SDI, and IPSS scores improved further. Conclusions. Diet-induced weight loss induces rapid improvement of sexual, urinary, and endothelial function in obese diabetic men. A high-protein, carbohydrate-reduced, low-fat diet also reduces systemic inflammation and sustains these beneficial effects to 1 year.
AB - Introduction. Abdominal obesity and type 2 diabetes mellitus are associated with sexual and endothelial dysfunction, lower urinary tract symptoms (LUTS), and chronic systemic inflammation. Aim. To determine the effects of diet-induced weight loss and maintenance on sexual and endothelial function, LUTS, and inflammatory markers in obese diabetic men. Main Outcome Measures. Weight, waist circumference (WC), International Index of Erectile Function (IIEF-5) score, Sexual Desire Inventory (SDI) score, International Prostate Symptom Scale (IPSS) score, plasma fasting glucose and lipids, testosterone, sex hormone binding globulin (SHBG), inflammatory markers (high-sensitivity C-reactive protein [CRP] and interleukin-6 [IL-6]) and soluble E-selectin, and brachial artery flow-mediated dilatation (FMD) were measured at baseline, 8 weeks, and 52 weeks. Methods. Over 8 weeks, 31 abdominally obese (body mass index≥30kg/m2, WC≥102cm), type 2 diabetic men (mean age 59.7 years) received either a meal replacement-based low-calorie diet (LCD) ∼1,000kcal/day (N=19) or low-fat, high-protein, reduced-carbohydrate (HP) diet (N=12) prescribed to decrease intake by ∼600kcal/day. Subjects continued on, or were switched to, the HP diet for another 44 weeks. Results. At 8 weeks, weight and WC decreased by ∼10% and ∼5% with the LCD and HP diet, respectively. Both diets significantly improved plasma glucose, low-density lipoprotein (LDL), SHBG, IIEF-5, SDI and IPSS scores, and endothelial function (increased FMD, reduced soluble E-selectin). Erectile function, sexual desire, and urinary symptoms improved by a similar degree with both diets. CRP and IL-6 decreased with the HP diet. At 52 weeks, reductions in weight, WC, and CRP were maintained. IIEF-5, SDI, and IPSS scores improved further. Conclusions. Diet-induced weight loss induces rapid improvement of sexual, urinary, and endothelial function in obese diabetic men. A high-protein, carbohydrate-reduced, low-fat diet also reduces systemic inflammation and sustains these beneficial effects to 1 year.
KW - Diabetes mellitus
KW - Endothelial function
KW - Erectile dysfunction
KW - Obesity
KW - Sexual function
KW - Urinary tract symptoms
UR - http://www.scopus.com/inward/record.url?scp=80053566808&partnerID=8YFLogxK
U2 - 10.1111/j.1743-6109.2011.02417.x
DO - 10.1111/j.1743-6109.2011.02417.x
M3 - Article
C2 - 21819545
AN - SCOPUS:80053566808
SN - 1743-6095
VL - 8
SP - 2868
EP - 2875
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
IS - 10
ER -