Comparison of Coronary Atherosclerotic Volume in Patients With Glomerular Filtration Rates ≤60 Versus >60 ml/min/1.73 m2: A Meta-Analysis of Intravascular Ultrasound Studies

Stephen J. Nicholls; E. Murat Tuzcu; Amy Hsu; Kathy Wolski; Ilke Sipahi; Paul Schoenhagen; Timothy Crowe; Samir R. Kapadia; Stanley L. Hazen; Steven E. Nissen

doi:10.1016/j.amjcard.2006.10.038

Comparison of Coronary Atherosclerotic Volume in Patients With Glomerular Filtration Rates ≤60 Versus >60 ml/min/1.73 m²: A Meta-Analysis of Intravascular Ultrasound Studies

Stephen J. Nicholls, E. Murat Tuzcu, Amy Hsu, Kathy Wolski, Ilke Sipahi, Paul Schoenhagen, Timothy Crowe, Samir R. Kapadia, Stanley L. Hazen, Steven E. Nissen

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The relation between glomerular filtration rate (GFR) <60 ml/min/1.73 m² and the extent and progression of coronary atherosclerosis in 989 subjects with coronary artery disease was investigated. Despite being older, more likely to be women, and having a history of hypertension, diabetes, and bypass surgery, total atheroma volume and percent atheroma volume in subjects with a low GFR did not differ from subjects with a GFR >60 ml/kg/min. Similarly, there was no difference in progression rates of total atheroma volume and percent atheroma volume in patients with GFRs lower and higher than 60 ml/min/1.73 m² in response to a high rate of use of established preventive therapies. In conclusion, findings suggest that the increased incidence of clinical events in patients with impaired renal function may result from factors other than atherosclerotic burden.

Original language	English
Pages (from-to)	813-816
Number of pages	4
Journal	American Journal of Cardiology
Volume	99
Issue number	6
DOIs	https://doi.org/10.1016/j.amjcard.2006.10.038
Publication status	Published or Issued - 15 Mar 2007
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2006.10.038

Cite this

Nicholls, S. J., Tuzcu, E. M., Hsu, A., Wolski, K., Sipahi, I., Schoenhagen, P., Crowe, T., Kapadia, S. R., Hazen, S. L., & Nissen, S. E. (2007). Comparison of Coronary Atherosclerotic Volume in Patients With Glomerular Filtration Rates ≤60 Versus >60 ml/min/1.73 m²: A Meta-Analysis of Intravascular Ultrasound Studies. American Journal of Cardiology, 99(6), 813-816. https://doi.org/10.1016/j.amjcard.2006.10.038

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title = "Comparison of Coronary Atherosclerotic Volume in Patients With Glomerular Filtration Rates ≤60 Versus >60 ml/min/1.73 m2: A Meta-Analysis of Intravascular Ultrasound Studies",

abstract = "The relation between glomerular filtration rate (GFR) <60 ml/min/1.73 m2 and the extent and progression of coronary atherosclerosis in 989 subjects with coronary artery disease was investigated. Despite being older, more likely to be women, and having a history of hypertension, diabetes, and bypass surgery, total atheroma volume and percent atheroma volume in subjects with a low GFR did not differ from subjects with a GFR >60 ml/kg/min. Similarly, there was no difference in progression rates of total atheroma volume and percent atheroma volume in patients with GFRs lower and higher than 60 ml/min/1.73 m2 in response to a high rate of use of established preventive therapies. In conclusion, findings suggest that the increased incidence of clinical events in patients with impaired renal function may result from factors other than atherosclerotic burden.",

author = "Nicholls, \{Stephen J.\} and Tuzcu, \{E. Murat\} and Amy Hsu and Kathy Wolski and Ilke Sipahi and Paul Schoenhagen and Timothy Crowe and Kapadia, \{Samir R.\} and Hazen, \{Stanley L.\} and Nissen, \{Steven E.\}",

note = "Funding Information: Dr. Nicholls was supported by a Ralph Reader Overseas Research Fellowship from the National Heart Foundation of Australia, Melbourne, Australia. REVERSAL and CAMELOT were funded by Pfizer, New York, New York. ACTIVATE was sponsored by Sankyo, Pharma, Tokyo, Japan. ",

year = "2007",

month = mar,

day = "15",

doi = "10.1016/j.amjcard.2006.10.038",

language = "English",

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Nicholls, SJ, Tuzcu, EM, Hsu, A, Wolski, K, Sipahi, I, Schoenhagen, P, Crowe, T, Kapadia, SR, Hazen, SL & Nissen, SE 2007, 'Comparison of Coronary Atherosclerotic Volume in Patients With Glomerular Filtration Rates ≤60 Versus >60 ml/min/1.73 m²: A Meta-Analysis of Intravascular Ultrasound Studies', American Journal of Cardiology, vol. 99, no. 6, pp. 813-816. https://doi.org/10.1016/j.amjcard.2006.10.038

Comparison of Coronary Atherosclerotic Volume in Patients With Glomerular Filtration Rates ≤60 Versus >60 ml/min/1.73 m²: A Meta-Analysis of Intravascular Ultrasound Studies. / Nicholls, Stephen J.; Tuzcu, E. Murat; Hsu, Amy et al.
In: American Journal of Cardiology, Vol. 99, No. 6, 15.03.2007, p. 813-816.

Research output: Contribution to journal › Article › peer-review

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AU - Nicholls, Stephen J.

AU - Tuzcu, E. Murat

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AU - Crowe, Timothy

AU - Kapadia, Samir R.

AU - Hazen, Stanley L.

AU - Nissen, Steven E.

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PY - 2007/3/15

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AB - The relation between glomerular filtration rate (GFR) <60 ml/min/1.73 m2 and the extent and progression of coronary atherosclerosis in 989 subjects with coronary artery disease was investigated. Despite being older, more likely to be women, and having a history of hypertension, diabetes, and bypass surgery, total atheroma volume and percent atheroma volume in subjects with a low GFR did not differ from subjects with a GFR >60 ml/kg/min. Similarly, there was no difference in progression rates of total atheroma volume and percent atheroma volume in patients with GFRs lower and higher than 60 ml/min/1.73 m2 in response to a high rate of use of established preventive therapies. In conclusion, findings suggest that the increased incidence of clinical events in patients with impaired renal function may result from factors other than atherosclerotic burden.

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